Monomethyl kolavate | CAS:24513-41-5 | Manufacturer ChemFaces

Monomethyl kolavate

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Product Name	Monomethyl kolavate
Price:
CAS No.:	24513-41-5
Catalog No.:	CFN98262
Molecular Formula:	C₂₁H₃₂O₄
Molecular Weight:	348.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The woods of Gossweilerodendron balsamiferum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Monomethyl kolavate is a power Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) inhibitor, with an IC50 value of 12uM.

Targets:

Antifection

In vitro:

Molecules. 2015 Sep 3;20(9):16154-69.

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.[Pubmed: 26404225 ]

As part of our ongoing efforts to identify natural products with activity against pathogens causing neglected tropical diseases, we are currently performing an extensive screening of natural product (NP) databases against a multitude of protozoan parasite proteins.
METHODS AND RESULTS:
Within this project, we screened a database of NPs from a commercial supplier, AnalytiCon Discovery (Potsdam, Germany), against Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH), a glycolytic enzyme whose inhibition deprives the parasite of energy supply. NPs acting as potential inhibitors of the mentioned enzyme were identified using a pharmacophore-based virtual screening and subsequent docking of the identified hits into the active site of interest. In a set of 700 structures chosen for the screening, 13 (1.9%) were predicted to possess significant affinity towards the enzyme and were therefore tested in an in vitro enzyme assay using recombinant TbGAPDH. Nine of these in silico hits (69%) showed significant inhibitory activity at 50 µM, of which two geranylated benzophenone derivatives proved to be particularly active with IC50 values below 10 µM.
CONCLUSIONS:
These compounds also showed moderate in vitro activity against T. brucei rhodesiense and may thus represent interesting starting points for further optimization.

Monomethyl kolavate Description

Source:	The woods of Gossweilerodendron balsamiferum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Diterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8694 mL	14.3472 mL	28.6944 mL	57.3888 mL	71.736 mL
5 mM	0.5739 mL	2.8694 mL	5.7389 mL	11.4778 mL	14.3472 mL
10 mM	0.2869 mL	1.4347 mL	2.8694 mL	5.7389 mL	7.1736 mL
50 mM	0.0574 mL	0.2869 mL	0.5739 mL	1.1478 mL	1.4347 mL
100 mM	0.0287 mL	0.1435 mL	0.2869 mL	0.5739 mL	0.7174 mL

CFN99325	Scutebata E	1207181-61-0	520.6	C₂₈H₄₀O₉
CFN99326	Scutebata F	1207181-62-1	555.6	C₃₀H₃₇NO₉
CFN99327	Scutebata G	1207181-63-2	679.8	C₄₀H₄₁NO₉
CFN96994	6-O-Nicotinoylscutebarbatine G	1206805-30-2	576.64	C₃₂H₃₆N₂O₈
CFN96705	Scutebarbatine W	1312716-25-8	575.65	C₃₃H₃₇NO₈
CFN97783	2-Oxokolavelool	221466-41-7	304.47	C₂₀H₃₂O₂
CFN97792	Kolavenol	19941-83-4	290.49	C₂₀H₃₄O
CFN97832	2-Oxokolavenol	130395-82-3	304.47	C₂₀H₃₂O₂
CFN96984	16-Oxocleroda-3,13E-dien-15-oic acid	117620-72-1	318.45	C₂₀H₃₀O₃
CFN98262	Monomethyl kolavate	24513-41-5	348.5	C₂₁H₃₂O₄