Science | Nature | Cell | View More
Natural Products
Magnesium Lithospermate B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Magnesium Lithospermate B
Price:
CAS No.: 122021-74-3
Catalog No.: CFN90390
Molecular Formula: C36H28MgO16
Molecular Weight: 740.90 g/mol
Purity: >=98%
Type of Compound: Phenylpropanoids
Physical Desc.: Powder
Source: The roots of Salvia miltiorrhiza Bge.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • National Cancer Institute (USA)
  • Universite de Lille1 (France)
  • Korea Intitute of Science and T... (Korea)
  • FORTH-IMBB (Greece)
  • Kyushu University (Japan)
  • Tohoku University (Japan)
  • Technical University of Denmark (Denmark)
  • Calcutta University (India)
  • Harvard University (USA)
  • Tokyo Woman's Christian University (Japan)
  • University of Leipzig (Germany)
  • More...
Package
Featured Products
1,5-Dicaffeoylquinic acid

Catalog No: CFN90937
CAS No: 19870-46-3
Price: $138/20mg
Sodium Danshensu

Catalog No: CFN99163
CAS No: 67920-52-9
Price: $40/20mg
Erianin

Catalog No: CFN90204
CAS No: 95041-90-0
Price: $118/20mg
6',7'-Dihydroxybergamottin

Catalog No: CFN98307
CAS No: 264234-05-1
Price: $318/10mg
1-Dehydro-6-gingerdione

Catalog No: CFN92298
CAS No: 76060-35-0
Price: $258/10mg
Harpagoside

Catalog No: CFN98147
CAS No: 19210-12-9
Price: $70/20mg
Lucidenic acid A

Catalog No: CFN90574
CAS No: 95311-94-7
Price: $318/20mg
Punicalin

Catalog No: CFN98113
CAS No: 65995-64-4
Price: $218/20mg
Cyanidin-3-O-arabinoside chloride

Catalog No: CFN92041
CAS No: 111613-04-8
Price: $318/10mg
Prim-O-glucosylcimifugin

Catalog No: CFN98104
CAS No: 80681-45-4
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Magnesium lithospermate B is a naturally occurring, new generation antioxidant that activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling. Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase, it provides anti-ischemic neuroprotection in gerbilssubjected to focal ischemia and reperfusion. Magnesium lithospermate B has potent antifibrotic effect in intraperitoneal thioacetamide (TAA)-treated cirrhotic rats, and inhibits fibrogenic responses in hepatic stellate cells (HSCs). It has depressor action on blood pressure in spontaneously hypertensive rats.Magnesium lithospermate B also has anti-wrinkle and anti-aging effects on skin.
Targets: p65 | NF-kB | TGF-β/Smad | ROS | PDGFR
In vitro:
Acta Pharmacol. Sin., 2000, 21(9):855-8.
Free radical scavenging and inhibition of lipid peroxidation by Magnesium lithospermate B.[Pubmed: 11501171]
To study the effect of Magnesium Lithospermate B (Monomethyl lithospermate B,MLB) on the lipid peroxidation and on its free radical scavenging activity.
METHODS AND RESULTS:
MLB was incubated in rat tissue homogenate or in a free radical generating system. MLB induced inhibition of lipid peroxidation and its scavenging activity on superoxide anions and hydroxyl radicals was studied using colorimetric estimation.MLB inhibited the lipid peroxidation induced by either an auto-oxidant or Fe2+/VitC in vitro, in the liver homogenate, the inhibitory rate of MLB (10 mg/L) being 69.2% and 57.7%, respectively. MLB (25 and 50 mg/kg) decreased the amount of thiobarbituric acid reactive substances (TBARS) in rat serum, liver, kidney, and heart. However, it did not inhibit the lipid peroxidation of brain homogenate ex vivo. MLB scavenged superoxide anions generated from xanthine/xanthine oxidase system and iron-dependent hydroxyl radicals.
CONCLUSIONS:
MLB is an inhibitor of lipid peroxidation and scavenge superoxide anions and hydroxyl radicals both in vitro and ex vivo.
Magnesium Lithospermate B Description
Source: The roots of Salvia miltiorrhiza Bge.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Dehydrodicatechin A

Catalog No: CFN95451
CAS No: 36048-23-4
Price: $318/5mg
Ganoweberianic acid E

Catalog No: CFN95504
CAS No: 1309931-90-5
Price: $413/5mg
Tortoside B (Manglieside E)

Catalog No: CFN95390
CAS No: 190655-17-5
Price: $413/5mg
Nomilinic acid

Catalog No: CFN95559
CAS No: 35930-20-2
Price: $318/5mg
Cannabisin M

Catalog No: CFN95436
CAS No: 1831134-13-4
Price: $318/5mg
Ganoderic acid beta

Catalog No: CFN95537
CAS No: 217476-76-1
Price: $413/5mg
Iristectorin A-6''-O-glucoside

Catalog No: CFN95597
CAS No: 86849-71-0
Price: $413/5mg
New compound 2

Catalog No: CFN95181
CAS No: N/A
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3497 mL 6.7485 mL 13.4971 mL 26.9942 mL 33.7427 mL
5 mM 0.2699 mL 1.3497 mL 2.6994 mL 5.3988 mL 6.7485 mL
10 mM 0.135 mL 0.6749 mL 1.3497 mL 2.6994 mL 3.3743 mL
50 mM 0.027 mL 0.135 mL 0.2699 mL 0.5399 mL 0.6749 mL
100 mM 0.0135 mL 0.0675 mL 0.135 mL 0.2699 mL 0.3374 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Exp. Mol. Med., 2011, 43(6):341-9.
Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats.[Pubmed: 21499011 ]
Magnesium Lithospermate B (Monomethyl lithospermate B,MLB) is one of the major active components of Salvia miltiorrhizae. The anti-oxidative effects of Salvia miltiorrhizae have been previously reported. The aim of this study was to investigate the effect of purified MLB on hepatic fibrosis in rats and on the fibrogenic responses in hepatic stellate cells (HSCs).
METHODS AND RESULTS:
Hepatic fibrosis was induced in rats by intraperitoneal thioacetamide (TAA) injections over a period of 8 or 12 weeks. MLB was orally administered daily by gavage tube. Serum AST and ALT levels in TAA+ MLB group were significantly lower than those in TAA only group at week 8. Hepatic fibrosis was significantly attenuated in TAA+MLB group than in TAA only group at week 8 or 12. Activation of HSCs was also decreased in TAA+MLB group as compared to TAA only group. Hepatic mRNA expression of α-smooth muscle actin (α-SMA), TGF-β1, and collagen α1(I) was significantly decreased in TAA+MLB group as compared to TAA only group. Incubation with HSCs and MLB (>or=100 μM) for up to 48 h showed no cytotoxicity. MLB suppressed PDGF-induced HSC proliferation. MLB inhibited NF-ΚB transcriptional activation and monocyte chemotactic protein 1 (MCP-1) production in HSCs. MLB strongly suppressed H(2)O(2)-induced reactive oxygen species (ROS) generation in HSCs, and MLB inhibited type I collagen secretion in HSCs.
CONCLUSIONS:
We concluded that MLB has potent antifibrotic effect in TAA-treated cirrhotic rats, and inhibits fibrogenic responses in HSCs. These data suggest that MLB has potential as a novel therapy for hepatic fibrosis.
1,5-Dicaffeoylquinic acid

Catalog No: CFN90937
CAS No: 19870-46-3
Price: $138/20mg
Sodium Danshensu

Catalog No: CFN99163
CAS No: 67920-52-9
Price: $40/20mg
Erianin

Catalog No: CFN90204
CAS No: 95041-90-0
Price: $118/20mg
6',7'-Dihydroxybergamottin

Catalog No: CFN98307
CAS No: 264234-05-1
Price: $318/10mg
1-Dehydro-6-gingerdione

Catalog No: CFN92298
CAS No: 76060-35-0
Price: $258/10mg
Harpagoside

Catalog No: CFN98147
CAS No: 19210-12-9
Price: $70/20mg
Lucidenic acid A

Catalog No: CFN90574
CAS No: 95311-94-7
Price: $318/20mg
Punicalin

Catalog No: CFN98113
CAS No: 65995-64-4
Price: $218/20mg
Cyanidin-3-O-arabinoside chloride

Catalog No: CFN92041
CAS No: 111613-04-8
Price: $318/10mg
Prim-O-glucosylcimifugin

Catalog No: CFN98104
CAS No: 80681-45-4
Price: $40/20mg
Tags: buy Magnesium Lithospermate B | Magnesium Lithospermate B supplier | purchase Magnesium Lithospermate B | Magnesium Lithospermate B cost | Magnesium Lithospermate B manufacturer | order Magnesium Lithospermate B | Magnesium Lithospermate B distributor