| Description: |
Mosloflavanone is an antifungal and radical scavenging 2-hydroxyflavanone, it possesses strong anti-EV71 activity and decreased the formation of visible cytopathic effects, it also inhibits virus replication during the initial stage of virus infection, and inhibits viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; it shows dose-dependent inhibition of TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases. |
| Targets: |
TNF-α | IL-1β Receptor | NOS | Antifection |
| In vitro: |
| Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8. | | Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.[Pubmed: 27257010 ] | Severe complications associated with EV71 infections are a common cause of neonatal death. Lack of effective therapeutic agents for these infections underlines the importance of research for the development of new antiviral compounds.
METHODS AND RESULTS:
In the present study, the anti-EV71 activity of norwogonin, oroxylin A, and Mosloflavone from Scutellaria baicalensis Georgi was evaluated using a cytopathic effect (CPE) reduction method, which demonstrated that all three compounds possessed strong anti-EV71 activity and decreased the formation of visible CPEs. Norwogonin, oroxylin A, and Mosloflavone also inhibited virus replication during the initial stage of virus infection, and they inhibited viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. However, ribavirin has a relatively weaker efficacy compared to the other drugs.
CONCLUSIONS:
Therefore, these findings provide important information that will aid in the utilization of norwogonin, oroxylin A, and Mosloflavone for EV71 treatment. | | Nat Prod Res. 2013;27(23):2227-30. | | Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.[Pubmed: 23768253 ] |
METHODS AND RESULTS:
Herein, we report the isolation and immunomodulatory activity of 11 phytoconstituents, viz. 7 flavonoids, 3 pentacyclic triterpenes and 1 phytosterol of an unexplored plant Actinocarya tibetica Benth. Three flavones, 5-methoxy-6,7-methylenedioxyflavone (6), Mosloflavone (7) and negletein (8), showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.22, 0.71, 16.4 μM and 10.8, 7.8, 6.4 μM, respectively. These flavones also showed dose-dependent inhibition of TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A. Molecular modelling studies revealed orientation and interactions of flavones 6-8 in the active site of TNF-α.
CONCLUSIONS:
These flavones can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases. |
|
| In vivo: |
| Zhong Yao Cai. 2015 Jan;38(1):89-92. | | Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata.[Pubmed: 26214875] | To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata.
METHODS AND RESULTS:
The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice.
Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), β-sitosterol(7), lupeol(8), moslosooflavone (9), Mosloflavone (10), negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12).
CONCLUSIONS:
All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice. |
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