N1,N5,N10-(Z)-tri-p-coumaroylspermidine | CAS:131086-78-7

N1,N5,N10-(Z)-tri-p-coumaroylspermidine

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Description:

N1,N5,N10-(Z)-tri-p-coumaroylspermidine shows weak inhibition effect on [3H]-5-HT reuptake in rat brain synaptosomes.

In vitro:

Journal of Shanxi Medical University, 2015.

Isolation and purification of coumaroylspermidines from Carthamus tinctorius L. and their inhibition effects on [~3H]-5-HT reuptake.[Reference: WebLink]

To isolate and purify coumaroylspermidines from Carthamus tinctorius L.,and to investigate their inhibition effects on [3H]-5-HT reuptake and the photoisomerization behavior of coumaroylspermidines.
METHODS AND RESULTS:
Coumaroyl spermidines were isolated and purified by medium pressure flash chromatography,Sephadex LH-20 column chromatographies and preparative HPLC. The chemical structures were identified by ESI-MS and1H-NMR. The inhibition effects of coumaroylspermidines on [3H]-5-HT reuptake in rat brain synaptosomes were studied by classical method. Photoisomerization behaviors of coumaroylspermidines were investigated by HPLC. Results Four coumaroylspermidines were isolated and identified as N1,N5,N10-(Z)-tri-p-coumaroylspermidine(1), N1,N5-( Z)-N10-( E)-tri-p-coumaroylspermidine(2),N1( E)-N5-( Z)-N10-( E)-tri-p-coumaroylspermidine(3),N1,N5,N10-( E)-tri-pcoumaroylspermidine(4). Coumaroylspermidine 2 and 3 showed better inhibition effects on [3H]-5-HT reuptake in rat brain synaptosomes,while coumaroylspermidine 1 showed weaker inhibition effect. The photoisomerization behavior studies showed that the four coumaroylspermidines transformed into each other under sunlight and finally reached an equilibrium state.
CONCLUSIONS:
Coumaroylspermidines could have inhibition effects on 5-HT reuptake and the inhibition effects could be different for different isomers. Coumaroylspermidines are unstable and could show photoisomerization behavior under sunlight.

N1,N5,N10-(Z)-tri-p-coumaroylspermidine Description

Source:	The herbs of Helianthus annuus L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	N1,N5,N10-(Z)-tri-p-coumaroylspermidine
Price:	$238 / 5mg
CAS No.:	131086-78-7
Catalog No.:	CFN95253
Molecular Formula:	C₃₄H₃₇N₃O₆
Molecular Weight:	583.7 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Oil
Source:	The herbs of Helianthus annuus L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7132 mL	8.566 mL	17.1321 mL	34.2642 mL	42.8302 mL
5 mM	0.3426 mL	1.7132 mL	3.4264 mL	6.8528 mL	8.566 mL
10 mM	0.1713 mL	0.8566 mL	1.7132 mL	3.4264 mL	4.283 mL
50 mM	0.0343 mL	0.1713 mL	0.3426 mL	0.6853 mL	0.8566 mL
100 mM	0.0171 mL	0.0857 mL	0.1713 mL	0.3426 mL	0.4283 mL

CFN95253	N1,N5,N10-(Z)-tri-p-coumaroylspermidine	131086-78-7	583.7	C₃₄H₃₇N₃O₆
CFN95254	Safflospermidine B	N/A	583.7	C₃₄H₃₇N₃O₆
CFN95255	Safflospermidine A	N/A	583.7	C₃₄H₃₇N₃O₆
CFN95256	N1,N5,N10-(E)-tri-p-coumaroylspermidine	364368-18-3	583.7	C₃₄H₃₇N₃O₆