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NG,NG-Dimethylarginine dihydrochloride
NG,NG-Dimethylarginine dihydrochloride
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name NG,NG-Dimethylarginine dihydrochloride
Price:
CAS No.: 220805-22-1
Catalog No.: CFN90056
Molecular Formula: C8H20Cl2N4O2
Molecular Weight: 275.18 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source:
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: NG,NG-Dimethylarginine dihydrochloride is a reversible inhibitor of nitric oxide synthetase in vivo and in vitro.
Targets: NO
In vivo:
Lancet. 1992 Mar 7;339(8793):572-5.
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure.[Pubmed: 1347093]
Nitric oxide (NO), synthesised from L-arginine, contributes to the regulation of blood pressure and to host defence.
METHODS AND RESULTS:
We describe in-vitro and in-vivo evidence that NO synthesis can be inhibited by an endogenous compound, NG,NG-dimethylarginine (asymmetrical dimethylarginine, ADMA). In man, this inhibitor is found in plasma and more than 10 mg is excreted in urine over 24 h. However, in patients with end-stage chronic renal failure, who have little or no urine output, elimination is blocked and circulating concentrations of the inhibitor rise sufficiently to inhibit NO synthesis.
CONCLUSIONS:
Accumulation of endogenous ADMA, leading to impaired NO synthesis, might contribute to the hypertension and immune dysfunction associated with chronic renal failure.
NG,NG-Dimethylarginine dihydrochloride Description
Source:
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

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PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.634 mL 18.1699 mL 36.3399 mL 72.6797 mL 90.8496 mL
5 mM 0.7268 mL 3.634 mL 7.268 mL 14.5359 mL 18.1699 mL
10 mM 0.3634 mL 1.817 mL 3.634 mL 7.268 mL 9.085 mL
50 mM 0.0727 mL 0.3634 mL 0.7268 mL 1.4536 mL 1.817 mL
100 mM 0.0363 mL 0.1817 mL 0.3634 mL 0.7268 mL 0.9085 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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