Neuchromenin | CAS:180964-26-5 | Manufacturer ChemFaces

Neuchromenin

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Neuchromenin Description

Source:	The culture broth of Eupenicillium javanicum var. meloforme PF1181.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Natural Organic Compounds Symposium keynote speech (43), 2001: 497-502.

84(P-41) Determination of the Absolute Configuration of Microbial Metabolites, (-)-Neuchromenin, (-)-Nocardione A and (-)-Nocardione B by Their Synthesis[Reference: WebLink]

In 1996 (-)-Neuchromenin (1) was isolated from the culture broth of Eupenicillium javanicum var. meloforme PF1181 as an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 μg/ml. Its structure was deduced as 1 by extensive spectral analysis, although its absolute configuration remained unknown.
METHODS AND RESULTS:
In order to settle that stereochemical problem, we undertook the synthesis of both the enantiomers of Neuchromenin using both the enantiomers of known aldehyde (11). By synthesizing both (R) and (S) enantiomers of Neuchromenin, we found (S) enantiomer to be identical with the naturally occurring (-)-Neuchromenin. In 2000 two new furano-o-naphthoquinones, (-)-nocardione B (2) and (-)-nocardione A (3) were isolated as new tyrosine phosphatase inhibitors with moderate antifungal and cytotoxic activities. Due to the scarcity of the materials, their absolute configuration remained unknown. In order to solve this problem, we undertook a synthesis of optically active nocardiones with known absolute configuration. (R)-(+)-Nocardione B (2) and (S)-(-)-nocardione A (3) were synthesized by starting from the commercially available enantiomers of propylene oxide and 5-benzyloxy (or methoxy)-1-tetralone.
CONCLUSIONS:
As a result, the absolute configuration of the naturally occurring (-)-nocardione A and (-)-nocardione B was established as S.

Product Name	Neuchromenin
Price:
CAS No.:	180964-26-5
Catalog No.:	CFN89158
Molecular Formula:	C₁₃H₁₂O₅
Molecular Weight:	248.23 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The culture broth of Eupenicillium javanicum var. meloforme PF1181.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Neuroprotection Compound Library Activators Compound Library Phenols Compound Library

Description:	(-)-Neuchromenin is an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 ug/ml.
Targets:	NGF

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0285 mL	20.1426 mL	40.2852 mL	80.5704 mL	100.713 mL
5 mM	0.8057 mL	4.0285 mL	8.057 mL	16.1141 mL	20.1426 mL
10 mM	0.4029 mL	2.0143 mL	4.0285 mL	8.057 mL	10.0713 mL
50 mM	0.0806 mL	0.4029 mL	0.8057 mL	1.6114 mL	2.0143 mL
100 mM	0.0403 mL	0.2014 mL	0.4029 mL	0.8057 mL	1.0071 mL

CFN96879	Musellarin A	477565-36-9	324.37	C₂₀H₂₀O₄
CFN96885	Musellarin B	1392476-32-2	354.40	C₂₁H₂₂O₅
CFN96698	Musellarin C	1392476-33-3	354.40	C₂₁H₂₂O₅
CFN96876	Musellactone	907583-51-1	232.23	C₁₃H₁₂O₄
CFN89158	Neuchromenin	180964-26-5	248.23	C₁₃H₁₂O₅