Norwogonin | CAS:4443-09-8 | Manufacturer ChemFaces

Norwogonin

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More articles cited ChemFaces products.

Phytochemistry Letters22 Dec. 2016

J Agric Food Chem.2016 Sep 7

Evid Based Complement Alternat Med. 2016 May 24;

BMC Complement Altern Med.2017 Aug 9;

J Sci Food Agric. 2017 Mar

Biochem Biophys Res Commun. 2017 Dec 16;

Horticultural Science2016

Sci Rep. 2017 Apr 11;

PLoS One. 2017 Mar 9;

Ind Crops Prod.2014 Dec 1;62:173-178.

New Zealand Journal of Forestry Sci.2014, 44:17

Arch Toxicol. 2017 Mar 20.

Viruses. 2017 Oct 3;9(10).

Cytotechnology. 2017 Apr 3.

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Our products had been exported to the following research institutions and universities, And still growing.

University of Liège (Belgium)

Chiang Mai University (Thailand)

National Chung Hsing University (Taiwan)

Northeast Normal University Chan... (China)

Gyeongsang National University (Korea)

Instytut Nawozów Sztucznych w P... (Poland)

Copenhagen University (Denmark)

Heinrich-Heine-University Düsse... (Germany)

University of British Columbia (Canada)

Florida International University (USA)

Weizmann Institute of Science (Israel)

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Norwogonin Description

Source:	The roots of Scutellaria baicalensis Georgi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.

PMID: 29328914

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.

PMID: 29149595

Scientific Reports 2017 Dec 11;7(1):17332.
doi: 10.1038/s41598-017-17427-6.

PMID: 29230013

Molecules. 2017 Oct 27;22(11). pii: E1829.
doi: 10.3390/molecules22111829.

PMID: 29077044

J Cell Biochem. 2018 Feb;119(2):2231-2239.
doi: 10.1002/jcb.26385.

PMID: 28857247

Phytomedicine. 2018 Feb 1;40:37-47.
doi:10.1016/j.phymed.2017.12.030

PMID: 29496173

Kinase Assay:

Planta Med. 2002 Dec;68(12):1063-5.

Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.[Pubmed: 12494330]

Three flavonoids: Norwogonin, dihydroNorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase).
METHODS AND RESULTS:
Norwogonin (IC 50 = 1.1 microM), dihydroNorwogonin (IC 50 = 2.9 microM) and baicalein (IC 50 = 2.4 microM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1.
CONCLUSIONS:
From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.

CAS No.	4443-09-8	Price	$388 / 10mg
Catalog No.	CFN92218	Purity	>=98%
Molecular Weight	270.2	Type of Compound	Flavonoids
Formula	C₁₅H₁₀O₅	Physical Description	Yellow powder
Download	Manual COA MSDS	Similar structural	Comparison (Web)

Description:	Norwogonin(IC 50 = 1.1 microM) shows potent inhibitory activity toward VHR.
Targets:	VHR

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.701 mL	18.5048 mL	37.0096 mL	74.0192 mL	92.5241 mL
5 mM	0.7402 mL	3.701 mL	7.4019 mL	14.8038 mL	18.5048 mL
10 mM	0.3701 mL	1.8505 mL	3.701 mL	7.4019 mL	9.2524 mL
50 mM	0.074 mL	0.3701 mL	0.7402 mL	1.4804 mL	1.8505 mL
100 mM	0.037 mL	0.185 mL	0.3701 mL	0.7402 mL	0.9252 mL

CFN95009	6-Hydroxywogonin	76844-70-7	300.3	C₁₆H₁₂O₆
CFN98403	6-Methoxywogonin	3162-45-6	314.3	C₁₇H₁₄O₆
CFN96512	7,8-Dihydroxyflavone	38183-03-8	254.24	C₁₅H₁₀O₄
CFN98741	Chrysin	480-40-0	254.2	C₁₅H₁₀O₄
CFN97139	5-Hydroxy-7-acetoxyflavone	6674-40-4	296.3	C₁₇H₁₂O₅
CFN99409	5-Acetoxy-7-hydroxyflavone	132351-58-7	296.3	C₁₇H₁₂O₅
CFN97138	5,7-Diacetoxyflavone	6665-78-7	338.3	C₁₉H₁₄O₆
CFN98840	Tectochrysin	520-28-5	268.3	C₁₆H₁₂O₄
CFN90896	Chrysin dimethylether	21392-57-4	282.3	C₁₇H₁₄O₄
CFN92218	Norwogonin	4443-09-8	270.2	C₁₅H₁₀O₅