Odoroside H | CAS:18810-25-8 | Manufacturer ChemFaces

Odoroside H

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Description:

Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.

Targets:

Sodium Channel | ATPase | Potassium Channel

In vitro:

J Ethnopharmacol. 2011 Apr 12;134(3):781-8.

Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum.[Pubmed: 21291990]

For identification of the active constituents we investigated the anticancer activity of cardenolides from Streptocaulon tomentosum Wight & Arn. (Asclepiadaceae) and from Nerium oleander L. (Apocynaceae) which are both used against cancer in the traditional medicine in their region of origin.
METHODS AND RESULTS:
The antiproliferative activity of cardenolides isolated from roots of Streptocaulon tomentosum (IC(50)<1-15.3 μM after 2 days in MCF7) and of cardenolide containing fractions from the cold aqueous extract of Nerium oleander leaves ("Breastin", mean IC(50) 0.85 μg/ml in a panel of 36 human tumor cell lines), their influence on the cellular viability and on the cell cycle (block at the G2/M-phase or at the S-phase in tumor cells, respectively) were determined using different cell lines. The murine cell line L929 and normal non-tumor cells were not affected. Bioactivity guided fractionation of Breastin resulted in the isolation of the monoglycosidic cardenolides oleandrine, oleandrigeninsarmentoside, neritaloside, Odoroside H, and odoroside A (IC(50)-values between 0.010 and 0.071 μg/ml).
CONCLUSIONS:
The observed anticancer activities of extracts and isolated cardenolides are in agreement with the ethnomedicinal use of Streptocaulon tomentosum and Nerium oleander. The most active anticancer compounds from both species are monoglycosidic cardenolides possessing the 3β,14β-dihydroxy-5β-card-20(22)-enolide structure with or without an acetoxy group at C-16. The results indicate that the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.

In vivo:

Phytochemistry. 1999 Feb;50(3):435-8.

Bio-active cardenolides from the leaves of Nerium oleander.[Pubmed: 9933955]

METHODS AND RESULTS:
A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of Nerium oleander showing a central nervous system (CNS) depressant effect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and Odoroside H, have been isolated which exhibited CNS depressant activity in mice at a dose of 25 mg/kg. The structure of neridiginoside was elucidated as 3 beta-O-(D-diginosyl)-5 beta, 14 beta-dihydroxy-card-20(22)-enolide, using spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY, J-resolved, HMQC and HMBC).
CONCLUSIONS:
The known compounds have been indentified through spectral studies and comparison of data with those reported in the literature.

Odoroside H Description

Source:	The herbs of Nerium indicum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Odoroside H
Price:
CAS No.:	18810-25-8
Catalog No.:	CFN99868
Molecular Formula:	C₃₀H₄₆O₈
Molecular Weight:	534.7 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Nerium indicum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Steroids Compound Library Sodium Channel Inhibitor Library Potassium Channel Inhibitor Library ATPase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8702 mL	9.351 mL	18.7021 mL	37.4042 mL	46.7552 mL
5 mM	0.374 mL	1.8702 mL	3.7404 mL	7.4808 mL	9.351 mL
10 mM	0.187 mL	0.9351 mL	1.8702 mL	3.7404 mL	4.6755 mL
50 mM	0.0374 mL	0.187 mL	0.374 mL	0.7481 mL	0.9351 mL
100 mM	0.0187 mL	0.0935 mL	0.187 mL	0.374 mL	0.4676 mL

CFN70386	Cymarin	508-77-0	548.7	C₃₀H₄₄O₉
CFN70385	Convallatoxin	508-75-8	550.7	C₂₉H₄₂O₁₀
CFN70338	k-Strophanthoside	33279-57-1	873.0	C₄₂H₆₄O₁₉
CFN91787	Deslanoside	17598-65-1	943.09	C₄₇H₇₄O₁₉
CFN96196	Lanatoside C	17575-22-3	985.1	C₄₉H₇₆O₂₀
CFN93081	Periplocymarin	32476-67-8	534.69	C₃₀H₄₆O₈
CFN90513	Periplocin	13137-64-9	696.82	C₃₆H₅₆O₁₃
CFN90985	Periplogenin 3-[O-beta-glucopyranosyl-(1->4)-beta-sarmentopyranoside]	1253421-94-1	696.83	C₃₆H₅₆O₁₃
CFN98535	Digitoxin	71-63-6	764.94	C₄₁H₆₄O₁₃
CFN98536	Digoxin	20830-75-5	780.94	C₄₁H₆₄O₁₄