Ophiopogonin D' | CAS:65604-80-0 | Manufacturer ChemFaces

Ophiopogonin D'

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $146.9 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Harpagoside

Catalog No: CFN98147
CAS No: 19210-12-9
Price: $70/20mg

Taraxasterol acetate

Catalog No: CFN97104
CAS No: 6426-43-3
Price: $/mg

Mulberroside F

Catalog No: CFN90794
CAS No: 193483-95-3
Price: $288/10mg

Ergosterol

Catalog No: CFN98980
CAS No: 57-87-4
Price: $30/20mg

Abietic acid

Catalog No: CFN90587
CAS No: 514-10-3
Price: $40/20mg

Alismol

Catalog No: CFN97446
CAS No: 87827-55-2
Price: $318/10mg

Sesamin

Catalog No: CFN97034
CAS No: 607-80-7
Price: $40/20mg

Neogambogic acid

Catalog No: CFN90175
CAS No: 93772-31-7
Price: $258/20mg

Isorhamnetin-3-O-beta-D-Glucoside

Catalog No: CFN99757
CAS No: 5041-82-7
Price: $218/10mg

Doxycycline

Catalog No: CFN90251
CAS No: 564-25-0
Price: $ /

Description:

Ophiopogonin D' can activate SIRT1, it also noncompetitively inhibits UGT1A6 and UGT1A10.

Targets:

SIRT1 | UGT1A6 | UGT1A10

In vitro:

Evid Based Complement Alternat Med. 2014;2014:594354.

The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase.[Pubmed: 25530784]

The mechanism of shengmai injection- (SMI-) related drug-drug interaction remains unclear. Evaluation of the inhibition potential of SMI's ingredients towards UDP-glucuronosyltransferases (UGTs) activity will provide a new insight to understand SMI-related drug-drug interaction.
METHODS AND RESULTS:
In vitro incubation system to model UGT reaction was used. Recombinant UGT isoforms-catalyzed 4-methylumbelliferone (4-MU) glucuronidation and UGT1A4-catalyzed trifluoperazine (TFP) glucuronidation reactions were employed to phenotype the inhibition profile of maidong's components towards the activity of UGT isoforms. Different inhibition potential of maidong's components towards various UGT isoforms was observed. Based on the inhibition kinetic investigation results, ophiopogonin D (OD) noncompetitively inhibited UGT1A6 and competitively inhibited UGT1A8, Ophiopogonin D' (OD') noncompetitively inhibited UGT1A6 and UGT1A10, and ruscorectal (RU) exhibited competitive inhibition towards UGT1A4. The inhibition kinetic parameters were calculated to be 20.6, 40.1, 5.3, 9.0, and 0.02 μM, respectively.
CONCLUSIONS:
In combination with our previous results obtained for the inhibition of UGT isoforms by ginsenosides and wuweizi components, the important SMI ingredients exhibiting strong inhibition towards UGT isoforms were highlighted. All the results obtained in the present study provide a new insight to understand SMI-related drug-drug interaction.

Ophiopogonin D' Description

Source:	The roots of Ophiopogon japonicus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Anal Chem. 2015 May 19;87(10):5046-9.

Specific Turn-On Fluorescent Probe with Aggregation-Induced Emission Characteristics for SIRT1 Modulator Screening and Living-Cell Imaging.[Pubmed: 25903518]

SIRT1 is an important protein that catalyzes the nicotinamide adenine dinucleotide (NAD)(+)-dependent deacetylation reaction, which is regarded as a novel target to treat metabolic disorders and aging-related diseases. However, there is lack of appropriate approach for SIRT1 modulator screening and bioimaging of SIRT1 in living cells.
METHODS AND RESULTS:
We designed and synthesized a "turn-on" fluorescent probe by connecting a specifically recognized peptide to tetraphenylethene core. It exhibits excellent selectivity and sensitivity in homogeneous measurement of SIRT1 activity for screening both SIRT1 inhibitors and activators. 20(S)-ginsenoside Rg3 and Ophiopogonin D' were found to activate SIRT1. It was also successfully applied to monitor SIRT1 modulation in the cardiomyocytes as well as in the wild-type and SIRT1(-/-) mesenchymal stem cells.

Product Name	Ophiopogonin D'
Price:	$238 / 10mg
CAS No.:	65604-80-0
Catalog No.:	CFN90503
Molecular Formula:	C₄₄H₇₀O₁₆
Molecular Weight:	855.02 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The roots of Ophiopogon japonicus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1696 mL	5.8478 mL	11.6956 mL	23.3913 mL	29.2391 mL
5 mM	0.2339 mL	1.1696 mL	2.3391 mL	4.6783 mL	5.8478 mL
10 mM	0.117 mL	0.5848 mL	1.1696 mL	2.3391 mL	2.9239 mL
50 mM	0.0234 mL	0.117 mL	0.2339 mL	0.4678 mL	0.5848 mL
100 mM	0.0117 mL	0.0585 mL	0.117 mL	0.2339 mL	0.2924 mL

CFN90194	Liriope muscari baily saponins C	87480-46-4	855.02	C₄₄H₇₀O₁₄
CFN90503	Ophiopogonin D'	65604-80-0	855.02	C₄₄H₇₀O₁₆
CFN98537	Gracillin	19083-00-2	885.04	C₄₅H₇₂O₁₇
CFN90255	Polyphyllin D	50773-41-6	855.02	C₄₄H₇₀O₁₆
CFN99516	Dioscin	19057-60-4	869.05	C₄₅H₇₂O₁₆
CFN99953	Polyphyllin II	76296-72-5	855.02	C₄₄H₇₀O₁₆
CFN90446	Polyphyllin E	76296-73-6	1015.18	C₅₁H₈₂O₂₀
CFN90447	Polyphyllin F	76296-74-7	1015.18	C₅₁H₈₂O₂₀