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Pachysamine M
Pachysamine M
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Pachysamine M
Price:
CAS No.: 1253202-75-3
Catalog No.: CFN89007
Molecular Formula: C28H44N2O2
Molecular Weight: 440.67 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Sarcococca ruscifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Pachysamine M shows inhibitory activities against multiple types of cancer cells.
Pachysamine M Description
Source: The roots of Sarcococca ruscifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2693 mL 11.3464 mL 22.6927 mL 45.3854 mL 56.7318 mL
5 mM 0.4539 mL 2.2693 mL 4.5385 mL 9.0771 mL 11.3464 mL
10 mM 0.2269 mL 1.1346 mL 2.2693 mL 4.5385 mL 5.6732 mL
50 mM 0.0454 mL 0.2269 mL 0.4539 mL 0.9077 mL 1.1346 mL
100 mM 0.0227 mL 0.1135 mL 0.2269 mL 0.4539 mL 0.5673 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry Letters, 2015, 14:31-34.
Pregnane alkaloids from Sarcococca ruscifolia and their cytotoxic activity. [Reference: WebLink]

METHODS AND RESULTS:
Six pregnane alkaloids were isolated from the root of Sarcococca ruscifolia. The structures of three new alkaloids, namely, sarcorucinine E-G (1-3), were elucidated using spectroscopic methods, while three known alkaloids, namely, epipachysamine D, Pachysamine M, and sarcovagine D, were identified by comparing their spectral data with those of the compounds reported earlier.
CONCLUSIONS:
All compounds were evaluated for their inhibitory activities against multiple types of cancer cells.
CFN98626Buxbodine B390362-51-3399.6 C26H41NO2
CFN98627Buxbodine D390362-53-5426.7 C28H46N2O
CFN99176Cyclovirobuxine860-79-7402.66C26H46N2O
CFN99385Pachyaximine A128255-08-3359.6 C24H41NO
CFN89007Pachysamine M1253202-75-3440.67C28H44N2O2
CFN99386Axillaridine A128255-16-3462.7 C30H42N2O2
CFN93072Buxtamine4236-73-1371.56C24H37NO2
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