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    Parisyunnanoside B
    Information
    CAS No. 945865-37-2 Price
    Catalog No.CFN90704Purity>=98%
    Molecular Weight1016.0Type of CompoundSteroids
    FormulaC50H80O21Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Our products had been exported to the following research institutions and universities, And still growing.
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    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Steroids Compound Library
  • Biological Activity
    Description: Reference standards.
    In vitro:
    Planta Med. 2009 Mar;75(4):356-63.
    Steroidal saponins from the rhizome of Paris polyphylla and their cytotoxic activities.[Pubmed: 19085682 ]
    Two new furostanol saponins and one new spirostanol saponin were isolated from the rhizome of Paris polyphylla Smith var. yunnanensis, together with 18 known steroidal saponins.
    METHODS AND RESULTS:
    The structures of the new steroidal saponins were elucidated as 26-O-beta-D-glucopyranosyl-(25R)-5-ene-furost-3 beta, 17 alpha, 22 alpha, 26-tetrol-3-O-alpha-L-arabinofuranosyl-(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (2, parisyunnanoside A), 26-O-beta-D-glucopyranosyl-(25R)-5, 20 (22)-diene-furost-3 beta, 26-diol-3-O-alpha-L-arabinofuranosyl-(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (7, Parisyunnanoside B), and (25R)-spirost-5-ene-3 beta, 12 alpha-diol-3-O-alpha-L-rhamnopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (13, parisyunnanoside C) by MS and 1 D and 2 D NMR analysis. The isolated compounds were evaluated for their cytotoxicity against HL-60 human promyelocytic leukemia cells.
    CONCLUSIONS:
    Our results showed that the spirostanol framework of the aglycone and the terminal alpha-L-rhamnopyranosyl with 1-->2 linkage to the sugar chain of saponins at C-3 are essential for their high cytotoxicity, whereas the hydroxy group substitution at C-12 or C-17 of the aglycone causes a reduction in their activity.
    Parisyunnanoside B Description
    Source: The rhizomes of Paris yunnanensis Franch.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9843 mL 4.9213 mL 9.8425 mL 19.685 mL 24.6063 mL
    5 mM 0.1969 mL 0.9843 mL 1.9685 mL 3.937 mL 4.9213 mL
    10 mM 0.0984 mL 0.4921 mL 0.9843 mL 1.9685 mL 2.4606 mL
    50 mM 0.0197 mL 0.0984 mL 0.1969 mL 0.3937 mL 0.4921 mL
    100 mM 0.0098 mL 0.0492 mL 0.0984 mL 0.1969 mL 0.2461 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    《Journal of Jinan University(Natural Science & Medicine Edition)》 2014-01
    Chemical constituents of Paris polyphylla var. yunnanensis[Reference: WebLink]

    METHODS AND RESULTS:
    Thirteen compounds were obtained from the 30% ethanol eluting fraction of macroporous resin and their structures were elucidated by their spectral data and physicochemical properties,which were identified as calonysterone( 1),glycoside St-J( 2),methyl ester of glycoside St-J( 3),cussonoside B( 4),methyl 3, 4-dihydroxybenzoate( 5),α-ecdysone( 6),20-hydroxyecdysone( 7),pinnatasterone( 8),polyphyllin H( 9),polyphyllin Ⅶ( 10),parisaponin I( 11),Parisyunnanoside B( 12),polyphyllin Ⅱ( 13).
    CONCLUSIONS:
    Among them,compounds 1- 5 were obtained from the genus Paris for the first time,and 1- 6 were isolated from this plant for the first time.