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    Preskimmianine
    Preskimmianine
    Information
    CAS No. 38695-41-9 Price
    Catalog No.CFN96377Purity>=98%
    Molecular Weight303.4Type of CompoundAlkaloids
    FormulaC17H21NO4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    Preskimmianine Description
    Source: The root barks of Dictamnus dasycarpus.
    Biological Activity or Inhibitors: 1. Preskimmianine is the biogenetic precursor of skimmianine.
    2. Preskimmianine can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.296 mL 16.4799 mL 32.9598 mL 65.9196 mL 82.3995 mL
    5 mM 0.6592 mL 3.296 mL 6.592 mL 13.1839 mL 16.4799 mL
    10 mM 0.3296 mL 1.648 mL 3.296 mL 6.592 mL 8.2399 mL
    50 mM 0.0659 mL 0.3296 mL 0.6592 mL 1.3184 mL 1.648 mL
    100 mM 0.033 mL 0.1648 mL 0.3296 mL 0.6592 mL 0.824 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Preskimmianine References Information
    Citation [1]

    Tetrahedron Letters,1972,13(22):2199-202.

    Preskimmianine : The Biogenetic Precursor of Skimmianine from Dictamnus albus L[Reference: WebLink]
    From the above evidence, Preskimmianine must have the structure (1,R = CHej or II. The structure (1,R = CH,) has the same methoxyl substitution pattern as the firanoquinoline alkaloid skixmnianine (III) which has been shown to be a constituent of the whole plant Dictmus albus L. Since (1,R = CH,) would be a likely biogenetic precursor of skimmianine.
    Citation [2]

    J Enzyme Inhib Med Chem. 2012 Aug;27(4):490-4

    Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells.[Pubmed: 21827366 ]
    The methanolic extract of Dictamnus dasycarpus root barks afforded one new glycosidic quinoline alkaloid, 3-[1β-hydroxy-2-(β-D-glucopyranosyloxy)-ethyl)-4-methoxy-2(1H)-quinolinone (1), together with nine known compounds, Preskimmianine (2), 8-methoxy-N-methylflindersine (3), dictamine (4), γ-fagarine (5), halopine (6), skimmianine (7), dictangustine-A (8), iso-γ-fagarine (9), isomaculosidine (10). The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production.