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    Questinol
    Questinol
    Information
    CAS No. 35688-09-6 Price
    Catalog No.CFN89152Purity>=98%
    Molecular Weight300.26Type of CompoundAnthraquinones
    FormulaC16H12O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    Questinol Description
    Source: The cultures of the fungus Talaromyces stipitatus KUFA 0207.
    Biological Activity or Inhibitors: 1. Questinol exhibits significant anti-obesity activity.
    2. Questinol shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 and inhibit NO and PGE2 production.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3304 mL 16.6522 mL 33.3045 mL 66.6089 mL 83.2612 mL
    5 mM 0.6661 mL 3.3304 mL 6.6609 mL 13.3218 mL 16.6522 mL
    10 mM 0.333 mL 1.6652 mL 3.3304 mL 6.6609 mL 8.3261 mL
    50 mM 0.0666 mL 0.333 mL 0.6661 mL 1.3322 mL 1.6652 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.6661 mL 0.8326 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Questinol References Information
    Citation [1]

    Mar Drugs. 2017 May 16;15(5).

    A New Ergosterol Analog, a New Bis-Anthraquinone and Anti-Obesity Activity of Anthraquinones from the Marine Sponge-Associated Fungus Talaromyces stipitatus KUFA 0207.[Pubmed: 28509846]
    A new ergosterol analog, talarosterone (1) and a new bis-anthraquinone derivative (3) were isolated, together with ten known compounds including palmitic acid, ergosta-4,6,8(14),22-tetraen-3-one, ergosterol-5,8-endoperoxide, cyathisterone (2), emodin (4a), Questinol (4b), citreorosein (4c), fallacinol (4d), rheoemodin (4e) and secalonic acid A (5), from the ethyl acetate extract of the culture of the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207. The structures of the new compounds were established based on extensive 1D and 2D spectral analysis, and in the case of talarosterone (1), the absolute configurations of its stereogenic carbons were determined by X-ray crystallographic analysis. The structure and stereochemistry of cyathisterone (2) was also confirmed by X-ray analysis. The anthraquinones 4a-e and secalonic acid A (5) were tested for their anti-obesity activity using the zebrafish Nile red assay. Only citreorosein (4c) and Questinol (4b) exhibited significant anti-obesity activity, while emodin (4a) and secalonic acid A (5) caused toxicity (death) for all exposed zebrafish larvae after 24 h.
    Citation [2]

    J Microbiol Biotechnol. 2014 Oct;24(10):1346-53.

    Anti-inflammatory activity of questinol isolated from marine-derived fungus Eurotium amstelodami in lipopolysaccharide-stimulated RAW 264.7 macrophages.[Pubmed: 24986678]
    In the present study, an anthraquinone derivative, Questinol was successfully isolated from the broth extract of the marine-derived fungus Eurotium amstelodami for the first time. The structure of Questinol was determined based on the analysis of the MS and NMR spectral data as well as comparison of those data with the published data. Moreover, the anti-inflammatory effect of Questinol in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells was investigated. The results showed that Questinol did not exhibit cytotoxicity in LPS-stimulated RAW 264.7 cells up to 200 μM. Questinol could significantly inhibit NO and PGE2 production at indicated concentrations. Questinol was also found to inhibit the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6. Furthermore, the western blot analysis showed that Questinol suppressed the expression level of iNOS in a dose-dependent manner. However, Questinol could slightly inhibit the expression of COX-2 at the concentration of 200 μM. Therefore, our study suggests that Questinol might be selected as a promising agent for the prevention and therapy of inflammatory disease.