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(R)-O-isobutyroyllomatin
(R)-O-isobutyroyllomatin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name (R)-O-isobutyroyllomatin
Price: $413 / 5mg
CAS No.: 440094-38-2
Catalog No.: CFN95250
Molecular Formula: C18H20O5
Molecular Weight: 316.4 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The herbs of Prionosciadium watsoni
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $351.1 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: (R)-O-isobutyroyllomatin shows significant dose-dependent protection against oxidative stress, it also exhibits cell proliferative effects.
In vitro:
Bioorganic & Medicinal Chemistry Letters, 18 May 2017, 27(14):3065-3070
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.[Reference: WebLink]

METHODS AND RESULTS:
A new coumarin, (-)-cis-(3'R,4'R)-4'-O-angeloylkhellactone-3'-O-β-d-glucopyranoside (1) and two new chalcones, 3'-[(2E)-5-carboxy-3-methyl-2-pentenyl]-4,2',4'-trihydroxychalcone (4) and (±)-4,2',4'-trihydroxy-3'-{2-hydroxy-2-[tetrahydro-2-methyl-5-(1-methylethenyl)-2-furanyl]ethyl}chalcone (5) were isolated from the aerial parts of Angelica keiskei (Umbelliferae), together with six known compounds: (R)-O-isobutyroyllomatin (2), 3'-O-methylvaginol (3), (-)-jejuchalcone F (6), isoliquiritigenin (7), davidigenin (8), and (±)-liquiritigenin (9). The structures of the new compounds were determined by interpretation of their spectroscopic data including 1D and 2D NMR data. All known compounds (2, 3, and 6-9) were isolated as constituents of A. keiskei for the first time. To identify novel hepatocyte proliferation inducer for liver regeneration, 1-9 were evaluated for their cell proliferative effects using a Hep3B human hepatoma cell line.
CONCLUSIONS:
All isolates exhibited cell proliferative effects compared to untreated control (DMSO). Cytoprotective effects against oxidative stress induced by glucose oxidase were also examined on Hep3B cells and mouse fibroblast NIH3T3 cells and all compounds showed significant dose-dependent protection against oxidative stress.
(R)-O-isobutyroyllomatin Description
Source: The herbs of Prionosciadium watsoni
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1606 mL 15.8028 mL 31.6056 mL 63.2111 mL 79.0139 mL
5 mM 0.6321 mL 3.1606 mL 6.3211 mL 12.6422 mL 15.8028 mL
10 mM 0.3161 mL 1.5803 mL 3.1606 mL 6.3211 mL 7.9014 mL
50 mM 0.0632 mL 0.3161 mL 0.6321 mL 1.2642 mL 1.5803 mL
100 mM 0.0316 mL 0.158 mL 0.3161 mL 0.6321 mL 0.7901 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Sennoside B

Catalog No: CFN99904
CAS No: 128-57-4
Price: $40/20mg
Nodakenetin

Catalog No: CFN98788
CAS No: 495-32-9
Price: $188/20mg
Syringic acid

Catalog No: CFN98884
CAS No: 530-57-4
Price: $30/20mg
2'-Hydroxydaidzein

Catalog No: CFN97687
CAS No: 7678-85-5
Price: $ /
Pueroside A

Catalog No: CFN95177
CAS No: 100692-52-2
Price: $318/5mg
Gancaonin N

Catalog No: CFN95066
CAS No: 129145-52-4
Price: $463/5mg
Gartanin

Catalog No: CFN98428
CAS No: 33390-42-0
Price: $318/5mg
Caffeoyl alcohol

Catalog No: CFN70348
CAS No: 3598-26-3
Price: $318/10mg
Palmatine

Catalog No: CFN98459
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Berberine

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