Rabdosin B | CAS:84304-92-7 | Manufacturer ChemFaces

Rabdosin B

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Rabdosin B shows cytotoxic activity against three human tumour HepG2, GLC-82 and HL-60 cell lines, it induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. Rabdosin B at higher concentrations inhibits root growth by affecting both cell length in the mature region and division of meristematic cells.

In vitro:

J Chem Ecol. 2010 May;36(5):553-63.

Regulation of cell division and growth in roots of Lactuca sativa L. seedlings by the Ent-Kaurene diterpenoid rabdosin B.[Pubmed: 20376693]

METHODS AND RESULTS:
Rabdosin B, an ent-kaurene diterpenoid purified from the air-dried aerial parts of Isodon japonica (Burm.f) Hara var. galaucocalyx (maxin) Hara, showed a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in lettuce seedlings (Lactuca sativa L.). Lower concentrations of Rabdosin B (20-80 microM) significantly promoted root growth, but its higher levels at 120-200 microM, by contrast, had inhibitory effects. Additionally, all tested concentrations (10-40 microM) inhibited root hair development of seedlings in a dose-dependent manner. Further investigations on the underlying mechanism revealed that the promotion effect of Rabdosin B at the lower concentrations resulted from increasing the cell length in the mature region and enhancing the mitotic activity of meristematic cells in seedlings' root tips. In contrast, Rabdosin B at higher concentrations inhibited root growth by affecting both cell length in the mature region and division of meristematic cells.
CONCLUSIONS:
Comet assay and cell cycle analysis demonstrated that the decrease of mitotic activity of root meristematic cells was due to DNA damage induced cell cycle retardation of the G(2) phase and S phase at different times.

Rabdosin B Description

Source:	The herbs of Rabdosia japonica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Rabdosin B
Price:
CAS No.:	84304-92-7
Catalog No.:	CFN92264
Molecular Formula:	C₂₄H₃₂O₈
Molecular Weight:	448.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Cryst.
Source:	The herbs of Rabdosia japonica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Anti-plant-germination and growth Compound Library DNA damaging agents Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2297 mL	11.1483 mL	22.2965 mL	44.5931 mL	55.7414 mL
5 mM	0.4459 mL	2.2297 mL	4.4593 mL	8.9186 mL	11.1483 mL
10 mM	0.223 mL	1.1148 mL	2.2297 mL	4.4593 mL	5.5741 mL
50 mM	0.0446 mL	0.223 mL	0.4459 mL	0.8919 mL	1.1148 mL
100 mM	0.0223 mL	0.1115 mL	0.223 mL	0.4459 mL	0.5574 mL

CFN91482	Rabdophyllin G	82460-75-1	406.5	C₂₂H₃₀O₇
CFN92264	Rabdosin B	84304-92-7	448.5	C₂₄H₃₂O₈
CFN92312	Acetylexidonin	116368-90-2	490.6	C₂₆H₃₄O₉
CFN99886	Epieriocalyxin A	191545-24-1	344.4	C₂₀H₂₄O₅
CFN97416	Trichorabdal A	85329-59-5	346.4	C₂₀H₂₆O₅
CFN92433	Isodonal	16964-56-0	404.5	C₂₂H₂₈O₇
CFN92261	6-epi-Augustifolin	369390-94-3	376.5	C₂₁H₂₈O₆
CFN98721	Sculponeatin K	477529-70-7	346.4	C₂₀H₂₆O₅
CFN92263	Lushanrubescensin H	476640-22-9	390.5	C₂₂H₃₀O₆
CFN92316	Maoyecrystal E	675603-39-1	406.5	C₂₂H₃₀O₇