Ranaconitine | CAS:1360-76-5 | Manufacturer ChemFaces

Ranaconitine

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Description:

Ranaconitine has cardiotoxicity.

In vitro:

J Pharm Biomed Anal. 2017 Apr 15;137:84-89.

Assessment of in vitro cardiotoxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication.[Pubmed: 28104561 ]

Aconitum leucostomum Worosch is a traditional Chinese medicine (TCM) and has a broad spectrum of health effects, but with a narrow therapeutic window. It is important to identify both the therapeutic ingredients and the toxic components to better utilize this TCM.
METHODS AND RESULTS:
The present study investigated the cardiotoxicity of the selected compounds in Aconitum leucostomum Worosch. The effects of extract of A. leucostomum Worosch and the isolated compounds on cardiocardiomyocytes were evaluated in vitro. Five known compounds in this TCM, including three C18-diterpene alkaloids, lappaconitine (2), N-deacetyllappaconitine (3), and Ranaconitine (5), and two C19-diterpene alkaloids, delvestidine (1) and anthranoyllycoctonine (4), were isolated from A. leucostomum Worosch. The cardiotoxicity of these components and extract fractions, as measured by lactate dehydrogenase release and apoptosis, was ranked as follows, in descending order: delvestidine>anthranoyllycoctonine>pH 4 fraction>pH 8 fraction>aconitine>N-deacetyllappaconitine>Ranaconitine>lappaconitine. The cytotoxicity of these compounds was shown to be dose-dependent, with delvestidine (1) and anthranoyllycoctonine (4) being the two most toxic compounds to cardiomyocytes in our assays.
CONCLUSIONS:
These results provide a basis for future rational use of this TCM, reducing side effects while retaining therapeutic effects.

Ranaconitine Description

Source:	The roots of Aconitum sinomontanum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Ranaconitine
Price:	$258 / 20mg
CAS No.:	1360-76-5
Catalog No.:	CFN93555
Molecular Formula:	C₃₂H₄₄N₂O₉
Molecular Weight:	600.7 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Aconitum sinomontanum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cardiotoxicity Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6647 mL	8.3236 mL	16.6472 mL	33.2945 mL	41.6181 mL
5 mM	0.3329 mL	1.6647 mL	3.3294 mL	6.6589 mL	8.3236 mL
10 mM	0.1665 mL	0.8324 mL	1.6647 mL	3.3294 mL	4.1618 mL
50 mM	0.0333 mL	0.1665 mL	0.3329 mL	0.6659 mL	0.8324 mL
100 mM	0.0166 mL	0.0832 mL	0.1665 mL	0.3329 mL	0.4162 mL

CFN99501	Indaconitine	4491-19-4	629.82	C₃₄H₄₇NO₁₀
CFN96413	Yunaconitoline	259099-25-7	625.69	C₃₄H₄₃NO₁₀
CFN90373	Crassicauline A	79592-91-9	643.77	C₃₅H₄₉NO₁₀
CFN89452	Carmichaenine A	2065228-59-1	541.67	C₃₁H₄₃NO₇
CFN89453	Carmichaenine E	2065228-63-7	557.67	C₃₁H₄₃NO₈
CFN90689	Fuziline	80665-72-1	453.58	C₂₄H₃₉NO₇
CFN98580	Talatisamine	20501-56-8	421.57	C₂₄H₃₉NO₅
CFN96243	10-Hydroxyneoline	132362-42-6	453.6	C₂₄H₃₉NO₇
CFN96267	Neolinine	112515-37-4	423.6	C₂₃H₃₇NO₆
CFN89456	Carmichaenine B	2065228-60-4	439.54	C₂₃H₃₇NO₇