Rehmannic acid | CAS:467-81-2 | Manufacturer ChemFaces

Rehmannic acid

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Description:

Rehmannic acid and oleanolic acetate inhibit succinoxidase activity. Both Rehmannic acid and Icterogenin are potent uncouplers, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter.

Targets:

NADPH-oxidase

In vivo:

Biochemical Pharmacology.1968 Jun;17(6):1079–1089.

Inhibition of biliary secretion by icterogenin and related triterpenes-I. Effect of icterogenin, rehmannic acid and oleanolic acetate on liver mitochondria in vitro.[Reference: WebLink]

The effect of Icterogenin, Rehmannic acid and oleanolic acetate on respiration, mitochondrial structure and oxidative phosphorylation in rabbit and rat liver mitochondria was studied.
METHODS AND RESULTS:
All three substances at a concentration 1 × 1o−4 M and 5 × 10−5M inhibit the respiration of NAD-linked enzymes. Only Icterogenin in the concentration 1 × 10−5 M increased the respiration rate. The succinoxidase activity was inhibited by Rehmannic acid and oleanolic acetate. Icterogenin at the concentrations 1 × 10−4 M and 5 × 10−5 M did not cause any definite changes in respiration with succinate as substrate, but at the concentration 1 × 10-5 M the respiration was always increased.The substances were found to increase the mitochondrial membrane permeability and Icterogenin had a swelling effect of the large amplitude type. The oxidative phosphorylation was uncoupled by Icterogenin and Rehmannic acid and inhibited by oleanolic acetate. Rehmannic acid at a concentration 5 × 10−5 M almost completely abolished the phosphate uptake when glutamate was used as substrate. The effect of Icterogenin was less. The respiration with glutamate as substrate was inhibited 50 per cent by the former and to about 25 per cent by the latter.
CONCLUSIONS:
With succinate as substrate, both Rehmannic acid and Icterogenin were potent uncouplers, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter. The connection between chemical structure and effect on oxidative phosphorylation is discussed.

Rehmannic acid Description

Source:	The herbs of Lantana camara
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Rehmannic acid
Price:
CAS No.:	467-81-2
Catalog No.:	CFN97738
Molecular Formula:	C₃₅H₅₂O₅
Molecular Weight:	552.80 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Lantana camara
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Triterpenoids Compound Library NADPH-oxidase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.809 mL	9.0449 mL	18.0897 mL	36.1795 mL	45.2243 mL
5 mM	0.3618 mL	1.809 mL	3.6179 mL	7.2359 mL	9.0449 mL
10 mM	0.1809 mL	0.9045 mL	1.809 mL	3.6179 mL	4.5224 mL
50 mM	0.0362 mL	0.1809 mL	0.3618 mL	0.7236 mL	0.9045 mL
100 mM	0.0181 mL	0.0904 mL	0.1809 mL	0.3618 mL	0.4522 mL

CFN97080	3-O-Acetyloleanderolide	62498-83-3	514.8	C₃₂H₅₀O₅
CFN99269	Sculponeatic acid	1169806-02-3	470.7	C₃₀H₄₆O₄
CFN97145	Moronic acid	6713-27-5	454.7	C₃₀H₄₆O₃
CFN99079	Pyrocincholic acid methyl ester	107160-24-7	456.7	C₃₀H₄₈O₃
CFN99606	Camaric acid	146450-83-1	568.8	C₃₅H₅₂O₆
CFN97738	Rehmannic acid	467-81-2	552.80	C₃₅H₅₂O₅
CFN95709	Melliferone	377724-68-0	452.7	C₃₀H₄₄O₃
CFN90155	Liquidambaric lactone	185051-75-6	468.67	C₃₀H₄₄O₄
CFN96374	3beta-Acetoxy-11alpha,12alpha-epoxyoleanan-28,13beta-olide	35738-25-1	512.7	C₃₂H₄₈O₅
CFN96265	16-Deoxysaikogenin F	57475-62-4	456.7	C₃₀H₄₈O₃