Science | Nature | Cell | View More
Natural Products
Retusine
Retusine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Retusine
Price:
CAS No.: 480-86-4
Catalog No.: CFN00411
Molecular Formula: C16H25NO5
Molecular Weight: 311.38 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Crotalaria pallida Ait.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Melbourne (Australia)
  • Shanghai University of TCM (China)
  • University of Perugia (Italy)
  • University of Hull (United Kingdom)
  • The Australian National University (Australia)
  • Institute of Chinese Materia Me... (China)
  • University of Toronto (Canada)
  • University of Eastern Finland (Finland)
  • Universiti Sains Malaysia (Malaysia)
  • Seoul National University of Sc... (Korea)
  • University of British Columbia (Canada)
  • More...
Package
Featured Products
1-Caffeoylquinic acid

Catalog No: CFN99121
CAS No: 1241-87-8
Price: $350/10mg
Chebulanin

Catalog No: CFN92294
CAS No: 166833-80-3
Price: $ / mg
Benzoylhypacoitine

Catalog No: CFN90688
CAS No: 63238-66-4
Price: $188/20mg
Eupatilin

Catalog No: CFN90190
CAS No: 22368-21-4
Price: $68/20mg
Lupeol

Catalog No: CFN98913
CAS No: 545-47-1
Price: $40/20mg
Tricin

Catalog No: CFN98841
CAS No: 520-32-1
Price: $258/10mg
Noroxyhydrastinine

Catalog No: CFN90504
CAS No: 21796-14-5
Price: $318/5mg
Retronecine

Catalog No: CFN00322
CAS No: 480-85-3
Price: $ /
Mogroside IIe

Catalog No: CFN92191
CAS No: 88901-38-6
Price: $218/10mg
Sagittatoside A

Catalog No: CFN90139
CAS No: 118525-35-2
Price: $318/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Retusine has edema inhibition capacity, could be related to a reduction of the prostaglandin production. Retusine shows activity against the Gram-positive bacteria C. diphtheria and S. aureus.
Targets: NO | Antifection
In vitro:
Z Naturforsch C. 2004 Mar-Apr;59(3-4):237-43.
Anti-inflammatory constituents of Mortonia greggii Gray.[Pubmed: 15241934 ]
A new phytochemical study of Mortonia greggii (Celastraceae) afforded four friedelan derivatives (1-4), three lupanes (5-7), Retusine (8), two esterified polyhydroxyagarofurans (9-10), mortonin C (11) and photomortonin C (12).
METHODS AND RESULTS:
The anti-inflammatory activity on carrageenan and 12-O-tetradecanoylphorbol-13-acetate induced models of inflammation, as well as the ability to inhibit the nitric oxide (NO) produced by lipopolysaccharide-stimulated mouse peritoneal macrophages were evaluated for the main metabolites. Our results showed that the friedelan dehydrocanophyllic acid methyl ester (1) exhibits an anti-inflammatory effect which could be related to an inhibition of prostaglandin and NO production. The activity of lupeol (5), 29-hydroxylupeol (6) and 29-hydroxylupenone (7) might be involved with the prostanoid synthesis. The presence of the hydroxy groups in 6 appears to be important for activity.
CONCLUSIONS:
The edema inhibition capacity of Retusine (8) could be related to a reduction of the prostaglandin production. The agarofuran derivative 10 is an NO inhibitor whose activity is probably not involved in the synthesis of prostaglandins.
Ann Pharm Fr. 1997;55(6):262-8
Isolation, identification and antimicrobial activity of ombuoside from Stevia triflora.[Pubmed: 9453171]
From aerial parts of Stevia triflora DC the flavonol glycoside ombuoside (7,4'-di-O-methylquercetin-3-O-beta-rutinoside) has been isolated and identified on the basis of spectral data.
METHODS AND RESULTS:
Ombuoside and the synthetic derivatives octa-acetylombuoside, ombuine and Retusine were tested for antimicrobial activity against several strains of Gram-positive and Gram-negative bacteria and the yeast Candida albicans, using the agar diffusion method. The flavonol glycoside ombuoside and the respective aglycone ombuine, both exhibited moderated activity against Corynebacterium diphtheria, Staphylococcus aureus, Escherichia coli and Candida albicans. To a lesser degree, octaacetylombuoside and Retusine showed activity against the Gram-positive bacteria C. diphtheria and S. aureus, but proved to be inactive against Gram-negative bacteria and Candida albicans.
CONCLUSIONS:
These results indicate that the presence of free hydroxyl groups, either alcoholic or phenolic, is an important chemical feature for the expression of flavonol antimicrobial activity. It is worth noting that this is the first study reported on the antibacterial and antifungal activity of these substances.
Retusine Description
Source: The herbs of Crotalaria pallida Ait.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
New compound 17

Catalog No: CFN95466
CAS No: N/A
Price: $318/5mg
(1S,2S)-threo-Honokitriol

Catalog No: CFN95076
CAS No: 1099687-80-5
Price: $413/5mg
6-Hydroxy-7-methoxydihydroligustil...

Catalog No: CFN95289
CAS No: 210036-09-2
Price: $318/5mg
N-Methyldehydrococlaurine

Catalog No: CFN95588
CAS No: N/A
Price: $318/5mg
8-Epiloganin

Catalog No: CFN95478
CAS No: 79172-04-6
Price: $318/20mg
Isolappaol C

Catalog No: CFN95225
CAS No: 929905-15-7
Price: $333/10mg
Bergaptol-beta-glucopyranoside

Catalog No: CFN95186
CAS No: 131623-13-7
Price: $318/10mg
Astin A

Catalog No: CFN95187
CAS No: 151201-75-1
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2115 mL 16.0576 mL 32.1151 mL 64.2302 mL 80.2878 mL
5 mM 0.6423 mL 3.2115 mL 6.423 mL 12.846 mL 16.0576 mL
10 mM 0.3212 mL 1.6058 mL 3.2115 mL 6.423 mL 8.0288 mL
50 mM 0.0642 mL 0.3212 mL 0.6423 mL 1.2846 mL 1.6058 mL
100 mM 0.0321 mL 0.1606 mL 0.3212 mL 0.6423 mL 0.8029 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
1-Caffeoylquinic acid

Catalog No: CFN99121
CAS No: 1241-87-8
Price: $350/10mg
Chebulanin

Catalog No: CFN92294
CAS No: 166833-80-3
Price: $ / mg
Benzoylhypacoitine

Catalog No: CFN90688
CAS No: 63238-66-4
Price: $188/20mg
Eupatilin

Catalog No: CFN90190
CAS No: 22368-21-4
Price: $68/20mg
Lupeol

Catalog No: CFN98913
CAS No: 545-47-1
Price: $40/20mg
Tricin

Catalog No: CFN98841
CAS No: 520-32-1
Price: $258/10mg
Noroxyhydrastinine

Catalog No: CFN90504
CAS No: 21796-14-5
Price: $318/5mg
Retronecine

Catalog No: CFN00322
CAS No: 480-85-3
Price: $ /
Mogroside IIe

Catalog No: CFN92191
CAS No: 88901-38-6
Price: $218/10mg
Sagittatoside A

Catalog No: CFN90139
CAS No: 118525-35-2
Price: $318/5mg
Tags: buy Retusine | Retusine supplier | purchase Retusine | Retusine cost | Retusine manufacturer | order Retusine | Retusine distributor