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    Rubioncolin C
    Rubioncolin C
    Information
    CAS No. 132242-52-5 Price
    Catalog No.CFN89245Purity>=98%
    Molecular Weight442.46Type of CompoundQuinones
    FormulaC27H22O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    Rubioncolin C Description
    Source: The roots and rhizomes of Rubia podantha.
    Biological Activity or Inhibitors: 1. Rubioncolin C shows good cytotoxicity with IC50 value of 1.53 uM and NF-κB inhibitory activity with IC50 value of 2.97 uM.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2601 mL 11.3005 mL 22.6009 mL 45.2018 mL 56.5023 mL
    5 mM 0.452 mL 2.2601 mL 4.5202 mL 9.0404 mL 11.3005 mL
    10 mM 0.226 mL 1.13 mL 2.2601 mL 4.5202 mL 5.6502 mL
    50 mM 0.0452 mL 0.226 mL 0.452 mL 0.904 mL 1.13 mL
    100 mM 0.0226 mL 0.113 mL 0.226 mL 0.452 mL 0.565 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Rubioncolin C References Information
    Citation [1]

    Phytochemistry. 2017 Nov 10;145:153-160.

    Rubipodanones A-D, naphthohydroquinone dimers from the roots and rhizomes of Rubia podantha.[Pubmed: 29132078 ]
    Four previously undescribed naphthohydroquinone dimers named rubipodanones A-D, together with 19 known quinones containing three known napthohydroquinone dimers named Rubioncolin C, methyl 5-hydroxy-dinaphtho[1,2-2',3']furan-7,12-dione-6-carboxylate and rubialatin B, were isolated from the roots and rhizomes of Rubia podantha. Their structures and absolute configurations were determined mainly by NMR, X-ray diffraction, and computational methods. Rubipodanones C and D, the glycosides of rubipodanone A and a pair of C-3 epimer, are the first identified dimeric napthohydroquinone glycosides from the Rubia plants. All naphthohydroquinone dimers were evaluated for their cytotoxicities against ten tumor cell lines and effects on the tumor-associated NF-κB signaling pathway, and Rubioncolin C showed the best cytotoxicity with IC50 value of 1.53 μM and NF-κB inhibitory activity with IC50 value of 2.97 μM. These results also demonstrated that the key roles of C-3 configuration and sugar group for biological activities of rubipodanone C.