|Source:||The roots of Salvia sahendica.|
|Biological Activity or Inhibitors:||1. Sahandol shows antiprotozoal activity against P. falciparum and T. brucei rhodesiense.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||3.3737 mL||16.8685 mL||33.7371 mL||67.4741 mL||84.3426 mL|
|5 mM||0.6747 mL||3.3737 mL||6.7474 mL||13.4948 mL||16.8685 mL|
|10 mM||0.3374 mL||1.6869 mL||3.3737 mL||6.7474 mL||8.4343 mL|
|50 mM||0.0675 mL||0.3374 mL||0.6747 mL||1.3495 mL||1.6869 mL|
|100 mM||0.0337 mL||0.1687 mL||0.3374 mL||0.6747 mL||0.8434 mL|
Planta Med. 2013 Jan;79(2):150-6.
|Abietane diterpenoids from Salvia sahendica--antiprotozoal activity and determination of their absolute configurations.[Pubmed: 23299758 ]|
|In a screening of Iranian plants for antiprotozoal activity, an n-hexane extract of the roots of Salvia sahendica potently inhibited the growth of Plasmodium falciparum K1 strain. Subsequent HPLC-based activity profiling led to the identification of seven known and one new abietane-type diterpenoid. Structure elucidation was achieved by analysis of spectroscopic data including 1D and 2D NMR. The absolute configuration of Sahandol (7) and sahandone (8) were assigned by comparison of experimental ECD spectra with calculated ECD data, using time-dependent density functional theory and methanol as the solvent. In vitro biological activity against P. falciparum and Trypanosoma brucei rhodesiense STIB 900 strain and cytotoxicity in rat myoblast (L6) cells were determined. The IC50 values of the compounds ranged from 0.8 μM to over 8.8 μM against P. falciparum, and from 1.8 μM to over 32.3 μM against T. brucei rhodesiense. The cytotoxic IC50 values ranged from 0.5-15.5 μM. Selectivity indices for P. falciparum were 0.1 to 18.2, and 0.1 to 1.2 for T. brucei rhodesiense.|