Science | Nature | Cell | View More
Natural Products
Schisantherin D
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Schisantherin D
Price:
CAS No.: 64917-82-4
Catalog No.: CFN96704
Molecular Formula: C29H28O9
Molecular Weight: 520.53 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The rattan of Schisandra sphenanthera.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Lodz University of Technology (Poland)
  • Uniwersytet Gdański (Poland)
  • Florida International University (USA)
  • University of Stirling (United Kingdom)
  • Copenhagen University (Denmark)
  • University of Minnesota (USA)
  • Sri Sai Aditya Institute of Pha... (India)
  • Tohoku University (Japan)
  • Helmholtz Zentrum München (Germany)
  • University of Pretoria (South Africa)
  • University of Wuerzburg (Germany)
  • More...
Package
Featured Products
Monomethyl lithospermate

Catalog No: CFN91005
CAS No: 933054-33-2
Price: $333/10mg
Guanosine

Catalog No: CFN90925
CAS No: 118-00-3
Price: $30/20mg
5-O-Feruloylquinic acid

Catalog No: CFN92889
CAS No: 40242-06-6
Price: $318/10mg
Danshensu

Catalog No: CFN99539
CAS No: 22681-72-7
Price: $70/20mg
Armepavine

Catalog No: CFN93348
CAS No: 524-20-9
Price: $388/10mg
Ginkgolic acid C13:0

Catalog No: CFN98507
CAS No: 20261-38-5
Price: $168/20mg
Madecassic acid

Catalog No: CFN99914
CAS No: 18449-41-7
Price: $30/20mg
Sugiol

Catalog No: CFN92187
CAS No: 511-05-7
Price: $ / mg
Gracillin

Catalog No: CFN98537
CAS No: 19083-00-2
Price: $80/20mg
Schizandrin B

Catalog No: CFN99923
CAS No: 61281-37-6
Price: $50/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
Targets: HIV
In vitro:
Bioorg Med Chem. 1997 Aug;5(8):1715-23.
Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues.[Pubmed: 9313872]
Bioactivity-directed fractionation of an ethanolic extract of the stems of Kadsura interior led to the isolation and identification of 12 known lignans (1-12).
METHODS AND RESULTS:
Seven of these compounds (1, 6, 8-12) were active as anti-HIV agents. Gomisin G (11) exhibited the most potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively. Schisantherin D (6), kadsuranin (8), and schisandrin C (10) showed good activity with EC50 values of 0.5, 0.8, and 1.2 micrograms/mL, and TI values of 110, 56, and 33.3, respectively. Ten related synthetic biphenyl compounds, five variously substituted bismethylenedioxy, dimethoxy, and dimethoxycarbonyl isomers (18-22) and five brominated derivatives (23-27) also were evaluated for inhibitory activity against HIV-1 replication in acutely infected H9 cells.
Schisantherin D Description
Source: The rattan of Schisandra sphenanthera.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
2''-O-Galloylmyricitrin

Catalog No: CFN95046
CAS No: 56939-52-7
Price: $333/5mg
Platycodin J

Catalog No: CFN95395
CAS No: 1325614-80-9
Price: $318/5mg
3''-Galloylquercitrin

Catalog No: CFN95048
CAS No: 503446-90-0
Price: $368/5mg
Sativanone

Catalog No: CFN95388
CAS No: 70561-31-8
Price: $318/10mg
New compound 6

Catalog No: CFN95259
CAS No: N/A
Price: $413/5mg
9-O-Acetyl-fargesol

Catalog No: CFN95031
CAS No: 449172-61-6
Price: $413/5mg
New compound 15

Catalog No: CFN95413
CAS No: N/A
Price: $413/5mg
Daidzein-4',7-diglucoside

Catalog No: CFN95094
CAS No: 53681-67-7
Price: $288/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9211 mL 9.6056 mL 19.2112 mL 38.4224 mL 48.028 mL
5 mM 0.3842 mL 1.9211 mL 3.8422 mL 7.6845 mL 9.6056 mL
10 mM 0.1921 mL 0.9606 mL 1.9211 mL 3.8422 mL 4.8028 mL
50 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7684 mL 0.9606 mL
100 mM 0.0192 mL 0.0961 mL 0.1921 mL 0.3842 mL 0.4803 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Asian Nat Prod Res. 2013 Sep;15(9):934-40.
Four new lignans from Schisandra sphenanthera.[Pubmed: 23945017 ]

METHODS AND RESULTS:
Three new 7,8-secolignans, schisandlignans A-C (1, 2, and 4), one new dibenzocyclooctadiene lignan, schisandlignan D (5), together with nine known lignans 3',4'-dimethoxybenzoic acid (3″,4″-dimethoxyphenyl)-2-methyl-3-oxobutyl ester (3), gomisin J (6), rubrisandrin A(1b) (7), interiotherin B (8), Schisantherin D (9), ( - )-machilusin (10), ganschisandrine (11), henricine A (12), and (+)-1-hydroxy pinoresinol (13), were isolated from the rattan of Schisandra sphenanthera.
CONCLUSIONS:
Their structures were determined by analysis of 1D and 2D NMR spectroscopic data.
Monomethyl lithospermate

Catalog No: CFN91005
CAS No: 933054-33-2
Price: $333/10mg
Guanosine

Catalog No: CFN90925
CAS No: 118-00-3
Price: $30/20mg
5-O-Feruloylquinic acid

Catalog No: CFN92889
CAS No: 40242-06-6
Price: $318/10mg
Danshensu

Catalog No: CFN99539
CAS No: 22681-72-7
Price: $70/20mg
Armepavine

Catalog No: CFN93348
CAS No: 524-20-9
Price: $388/10mg
Ginkgolic acid C13:0

Catalog No: CFN98507
CAS No: 20261-38-5
Price: $168/20mg
Madecassic acid

Catalog No: CFN99914
CAS No: 18449-41-7
Price: $30/20mg
Sugiol

Catalog No: CFN92187
CAS No: 511-05-7
Price: $ / mg
Gracillin

Catalog No: CFN98537
CAS No: 19083-00-2
Price: $80/20mg
Schizandrin B

Catalog No: CFN99923
CAS No: 61281-37-6
Price: $50/20mg
Tags: buy Schisantherin D | Schisantherin D supplier | purchase Schisantherin D | Schisantherin D cost | Schisantherin D manufacturer | order Schisantherin D | Schisantherin D distributor