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    Scutebarbatine X
    Scutebarbatine X
    Information
    CAS No. 1312716-26-9 Price
    Catalog No.CFN96691Purity>=98%
    Molecular Weight634.68Type of CompoundDiterpenoids
    FormulaC34H38N2O10Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    Scutebarbatine X Description
    Source: The whole plants of Scutellaria barbata.
    Biological Activity or Inhibitors: 1. Scutebarbatine X can inhibit nitric oxide production efficiently with IC50 values of lower than 50 uM, it may have potential effects on the reduction of neuroinflammation.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5756 mL 7.878 mL 15.756 mL 31.5119 mL 39.3899 mL
    5 mM 0.3151 mL 1.5756 mL 3.1512 mL 6.3024 mL 7.878 mL
    10 mM 0.1576 mL 0.7878 mL 1.5756 mL 3.1512 mL 3.939 mL
    50 mM 0.0315 mL 0.1576 mL 0.3151 mL 0.6302 mL 0.7878 mL
    100 mM 0.0158 mL 0.0788 mL 0.1576 mL 0.3151 mL 0.3939 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Scutebarbatine X References Information
    Citation [1]

    Chem Pharm Bull (Tokyo). 2010 Sep;58(9):1267-70.

    Scutebarbatines W-Z, new neo-clerodane diterpenoids from Scutellaria barbata and structure revision of a series of 13-spiro neo-clerodanes.[Pubmed: 20823615]
    Four new neo-clerodane diterpenoids, scutebarbatine W, Scutebarbatine X, scutebarbatine Y, scutebarbatine Z (1-4), were isolated from the ethanol extract of Scutellaria barbata (Labiatae), and their structures were elucidated on the basis of extensive spectroscopic studies. In addition, the proposed structures of at least seven 13-spiro subtype neo-clerodanes: scutehenanine B (5), scutebarbatine G (6), 6-O-nicotinoylscutebarbatine G (7), barbatin A (8), 6,7-di-O-nicotinoylscutebarbatine G (9), 6-O-nicotinoyl-7-O-acetylscutebarbatine G (10), and scutebarbatine F (11), reported by Dai and co-workers from the same species, were incorrectly assigned and have been revised by reanalysis of the published NMR data.
    Citation [2]

    Chem Biodivers. 2017 Aug 14.

    Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-stimulated Microglial Cells.[Pubmed: 28805952]
    The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), scutebatas B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7) and Scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values. All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50 μM. Particularly, compound 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4 μM, respectively. This is the first report suggesting the potential of S. barbata on the reduction of neuroinflammation.