Segetalin A | CAS:161875-97-4 | Manufacturer ChemFaces

Segetalin A

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Description:

Segetalin A has estrogen-like activity.

Targets:

Estrogen receptor | Progestogen receptor

In vitro:

Fitoterapia. 2012 Jan;83(1):170-81.

Antiproliferative activity of Saponaria vaccaria constituents and related compounds.[Pubmed: 22056663 ]

METHODS AND RESULTS:
Total methanolic extracts of Saponaria vaccaria seed derived from several varieties, as well as various purified components obtained through successive chromatographic separations of total extracts were evaluated for their growth inhibitory activity in WiDr (colon), MDA-MB-231 (breast), NCI-417 (lung) and PC-3 (prostate) human cancer cells as well as the non-tumorigenic fibroblast BJ (CRL-2522) cell line using MTT colorimetric assay. Purified bisdesmosidic saponins segetoside H and I were further examined using microscopy and apoptosis assays. Bisdesmosidic saponins exhibited dose-dependent growth inhibitory and selective apoptosis-inducing activity. Growth inhibitory effects were particularly strong in a breast (MDA-MB-231) and a prostate (PC-3) cancer cell line. Total extracts exhibited a different preference being most active against a colon cancer cell line (WiDr). In a comparison of varieties, all of the total seed extracts exhibited similar dose-dependent activities, but with some variation in potency. Monodesmosidic saponins vaccarosides A and B, phenolic vaccarin, and cyclopeptide Segetalin A, co-occurring seed substituents, did not exhibit activity. The non-tumorigenic fibroblast cell line BJ (CRL 2522) was growth inhibited but did not undergo apoptosis when treated with bisdesmosidic saponins at low micromolar concentrations.
CONCLUSIONS:
Saponin-rich extracts from Kochia scoparia seed and Chenopodium quinoa were also evaluated alongside Saponaria saponins but did not exhibit activity. Closely related Quillaja saponins exhibited activity but were less potent.

Segetalin A Description

Source:	The herbs of Vaccaria segetalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Bioorg Med Chem. 1997 Mar;5(3):631-6.

Thionation of segetalins A and B, cyclic peptides with estrogen-like activity from seeds of Vaccaria segetalis.[Pubmed: 9113340]

METHODS AND RESULTS:
Thionation of estrogen-like active cyclic peptides, Segetalin A (1) and segetalins B (2), with Lawesson's reagent provided each two thiosegetalins; thioSegetalin A1 [Gly-1-psi(CS-NH)-Val-2; Trp-5-psi (CS-NH)-Ala-6]Segetalin A, thioSegetalin A2 [Gly-1-psi(CS-NH)-Val-2; Ala-6-psi(CS-NH)-Gly-1]Segetalin A, thiosegetalin B1 [Gly-1-psi (CS-NH)-Val-2; Ala-3-psi(CS-NH)-Trp-4]segetalin B, and thiosegetalin B2 [Gly-1-psi(CS-NH)-Val-2; Trp-4-psi(CS-NH)-Ala-1]segetalin B. ThioSegetalin A2 only showed estrogen-like activity against ovariectomized rats.
CONCLUSIONS:
On the basis of their conformations analysed by NMR experiments, the backbone conformation was considered to play an important role in estrogen-like activity for segetalins.

Product Name	Segetalin A
Price:	$368 / 5mg
CAS No.:	161875-97-4
Catalog No.:	CFN93198
Molecular Formula:	C₃₁H₄₃N₇O₆
Molecular Weight:	609.72 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Vaccaria segetalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library Progestogen receptor Inhibitor Library Estrogen receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6401 mL	8.2005 mL	16.401 mL	32.8019 mL	41.0024 mL
5 mM	0.328 mL	1.6401 mL	3.2802 mL	6.5604 mL	8.2005 mL
10 mM	0.164 mL	0.82 mL	1.6401 mL	3.2802 mL	4.1002 mL
50 mM	0.0328 mL	0.164 mL	0.328 mL	0.656 mL	0.82 mL
100 mM	0.0164 mL	0.082 mL	0.164 mL	0.328 mL	0.41 mL

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