Science | Nature | Cell | View More
Natural Products
Selinidin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Selinidin
Price:
CAS No.: 19427-82-8
Catalog No.: CFN90570
Molecular Formula: C19H20O5
Molecular Weight: 328.4 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The herbs of Peucedanum harry-smithii var. subglabrum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Leibniz Institute of Plant Bioc... (Germany)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Kyushu University (Japan)
  • University of Maryland (USA)
  • Universidad de Antioquia (Colombia)
  • University of Perugia (Italy)
  • Cancer Research Initatives Foun... (Malaysia)
  • Worcester Polytechnic Institute (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Universidad Industrial de Santa... (Colombia)
  • More...
Package
Featured Products
Ginsenoside Rc

Catalog No: CFN99973
CAS No: 11021-14-0
Price: $70/20mg
Padmatin

Catalog No: CFN97280
CAS No: 80453-44-7
Price: $268/5mg
Dehydroevodiamine

Catalog No: CFN90944
CAS No: 67909-49-3
Price: $50/20mg
Ferulic acid

Catalog No: CFN99158
CAS No: 1135-24-6
Price: $40/20mg
Methylenetanshinquinone

Catalog No: CFN92179
CAS No: 67656-29-5
Price: $338/5mg
Kaempferol-7-O-D-glucopyranoside

Catalog No: CFN90150
CAS No: 16290-07-6
Price: $268/5mg
Galangin

Catalog No: CFN98918
CAS No: 548-83-4
Price: $40/20mg
Umbelliferone

Catalog No: CFN97503
CAS No: 93-35-6
Price: $30/20mg
Quercetin 3-O-neohesperidoside

Catalog No: CFN91148
CAS No: 32453-36-4
Price: $318/10mg
Swertisin

Catalog No: CFN90621
CAS No: 6991-10-2
Price: $228/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
Targets: TNF-α | p38MAPK | IkB | IKK
In vitro:
Biol Pharm Bull. 2008 Mar;31(3):442-8.
Selinidin suppresses IgE-mediated mast cell activation by inhibiting multiple steps of Fc epsilonRI signaling.[Pubmed: 18310907]
IgE-mediated mast cell activation is critical for development of allergic inflammation. We have recently found that Selinidin, one of the coumarin derivatives isolated from Angelica keiskei, attenuates mast cell degranulation following engagement of the high-affinity receptor for IgE (Fc epsilonRI) with IgE and antigen.
METHODS AND RESULTS:
In the present study, we investigated the effects of Selinidin on intracellular signaling and mast cell activation employing bone marrow-derived mast cells. Here, we report that Selinidin attenuates the release of beta-hexosaminidase, synthesis of leukotriene C4, and production of tumor necrosis factor-alpha without affecting IgE-Fc epsilonRI binding. Furthermore, biochemical analyses of the Fc epsilonRI-mediated signaling pathway demonstrated that Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
CONCLUSIONS:
These results suggest that this compound suppresses IgE-mediated mast cell activation by inhibiting multiple steps of FcepsilonRI-dependent signaling pathways and would be beneficial for the prevention of allergic inflammation.
Selinidin Description
Source: The herbs of Peucedanum harry-smithii var. subglabrum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Methyl caffeate acid

Catalog No: CFN95561
CAS No: 3843-74-1
Price: $ / mg
Fragransin B1

Catalog No: CFN95443
CAS No: 112516-03-7
Price: $318/5mg
N-Demethylfordianoside

Catalog No: CFN95589
CAS No: N/A
Price: $318/10mg
Eriodictyol 7-O-glucuronide

Catalog No: CFN95290
CAS No: 125535-06-0
Price: $318/10mg
Methyl lucidenate A

Catalog No: CFN95583
CAS No: 105742-79-8
Price: $318/5mg
Isomargaritene

Catalog No: CFN95304
CAS No: 64271-11-0
Price: $318/10mg
New compound 20

Catalog No: CFN95545
CAS No: N/A
Price: $413/5mg
Glicoricone

Catalog No: CFN95063
CAS No: 161099-37-2
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0451 mL 15.2253 mL 30.4507 mL 60.9013 mL 76.1267 mL
5 mM 0.609 mL 3.0451 mL 6.0901 mL 12.1803 mL 15.2253 mL
10 mM 0.3045 mL 1.5225 mL 3.0451 mL 6.0901 mL 7.6127 mL
50 mM 0.0609 mL 0.3045 mL 0.609 mL 1.218 mL 1.5225 mL
100 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.609 mL 0.7613 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Ginsenoside Rc

Catalog No: CFN99973
CAS No: 11021-14-0
Price: $70/20mg
Padmatin

Catalog No: CFN97280
CAS No: 80453-44-7
Price: $268/5mg
Dehydroevodiamine

Catalog No: CFN90944
CAS No: 67909-49-3
Price: $50/20mg
Ferulic acid

Catalog No: CFN99158
CAS No: 1135-24-6
Price: $40/20mg
Methylenetanshinquinone

Catalog No: CFN92179
CAS No: 67656-29-5
Price: $338/5mg
Kaempferol-7-O-D-glucopyranoside

Catalog No: CFN90150
CAS No: 16290-07-6
Price: $268/5mg
Galangin

Catalog No: CFN98918
CAS No: 548-83-4
Price: $40/20mg
Umbelliferone

Catalog No: CFN97503
CAS No: 93-35-6
Price: $30/20mg
Quercetin 3-O-neohesperidoside

Catalog No: CFN91148
CAS No: 32453-36-4
Price: $318/10mg
Swertisin

Catalog No: CFN90621
CAS No: 6991-10-2
Price: $228/10mg
Tags: buy Selinidin | Selinidin supplier | purchase Selinidin | Selinidin cost | Selinidin manufacturer | order Selinidin | Selinidin distributor