| Description: |
Sweroside possesses wound healing, cytoprotective, skin-whitening , anti-osteoporotic
, and hepatoprotective effect. It can inhibit potent melanogenesis in melan-a cells at 300uM without cytotoxicity, also decreases tyrosinase, tyrosinase-related protein-1 (TRP-1) and TRP-2 protein production in melan a cells. It
also shows insulin-mimicking effects on the regulation of Pck1 expression. |
| In vitro: |
| Planta Med. 2006 Mar;72(4):289-94. | | Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts.[Pubmed: 16557467] | Wound healing properties of Gentian (Gentiana lutea ssp. symphyandra) extract and its main constituents, gentiopicroside, Sweroside and swertiamarine (compounds 1-3, respectively) were evaluated by comparison with dexpanthenol on cultured chicken embryonic fibroblasts.
METHODS AND RESULTS:
The extract was also analyzed by HPLC to quantify its constituents. Chicken embryonic fibroblasts from fertilized eggs were incubated with the plant extract and its constituents, compounds 1-3. Using microscopy, mitotic ability, morphological changes and collagen production in the cultured fibroblasts were evaluated as parameters. Wound healing activity of Gentian seems to be mainly due to the increase in the stimulation of collagen production and the mitotic activity by compounds 2 and 3, respectively (p < 0.005 in all cases).
CONCLUSIONS:
All three compounds also exhibited cytoprotective effects, which may cause a synergism in terms of wound healing activity of Gentian. The findings demonstrated the wound healing activity of Gentian, which has previously been based only on ethnomedical data. | | Chem Biol Interact. 2015 Aug 5;238:33-9. | | Modulation effects of sweroside isolated from the Lonicera japonica on melanin synthesis.[Pubmed: 26051519] | In the course of screening for the melanogenesis inhibitors, Sweroside was isolated from Lonicera japonica. Its chemical structure was determined on the basis of spectroscopic analysis, including mass spectroscopy and nuclear magnetic resonance analysis.
METHODS AND RESULTS:
Sweroside inhibited potent melanogenesis in melan-a cells at 300μM without cytotoxicity. Also, Sweroside decreased tyrosinase, tyrosinase-related protein-1 (TRP-1) and TRP-2 protein production in melan a cells. To identify the signaling pathway of Sweroside, the ability of Sweroside to influence Akt and extracellular signal-regulated protein kinase (ERK) activation was investigated. Sweroside induced Akt and ERK in a dose-dependent manner. In addition, the specific inhibition of the Akt and ERK signaling pathways were studied by specific inhibitor LY294002 and U0126, respectively and it was causing the increased melanin synthesis. Furthermore, Sweroside presented inhibition of the body pigmentation and tyrosinase activity in zebrafish in vivo model.
CONCLUSIONS:
These results suggest that Sweroside isolated from L. japonica may be an effective skin-whitening agent through the regulates the expression of MAP kinase and melanogenic enzymes. |
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