Tetrahydroxysqualene | CAS:1043629-23-7

Tetrahydroxysqualene

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Product Name	Tetrahydroxysqualene
Price:
CAS No.:	1043629-23-7
Catalog No.:	CFN99062
Molecular Formula:	C₃₀H₅₀O₄
Molecular Weight:	474.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The barks of Toxicodendron vernicifluum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Tetrahdroxysqualene shows antimycobacterial activity with an MIC of 10.0 microg/mL, while showing only modest cytotoxicity.

Targets:

Antifection

In vitro:

J Nat Prod. 2008 Sep;71(9):1623-4.

Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis.[Pubmed: 18710283]

Tuberculosis has become a major health problem, in particular with the emergence of extremely drug resistant tuberculosis (XDRTB).
METHODS AND RESULTS:
In our search for new therapeutic leads against TB, we isolated a new triterpene (1) from the plant Rhus taitensis collected in Papua New Guinea. Tetrahydroxysqualene (1) was isolated using bioassay-guided fractionation of the methanolic extract of R. taitensis leaves and twigs. The structure of Tetrahydroxysqualene (1) was elucidated on the basis of HRESIMS and 1D and 2D NMR spectra.
CONCLUSIONS:
Tetrahydroxysqualene (1) exhibited antituberculosis activity with an MIC of 10.0 microg/mL, while showing only modest cytotoxicity.

Tetrahydroxysqualene Description

Source:	The barks of Toxicodendron vernicifluum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Triterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1066 mL	10.533 mL	21.0659 mL	42.1319 mL	52.6648 mL
5 mM	0.4213 mL	2.1066 mL	4.2132 mL	8.4264 mL	10.533 mL
10 mM	0.2107 mL	1.0533 mL	2.1066 mL	4.2132 mL	5.2665 mL
50 mM	0.0421 mL	0.2107 mL	0.4213 mL	0.8426 mL	1.0533 mL
100 mM	0.0211 mL	0.1053 mL	0.2107 mL	0.4213 mL	0.5266 mL

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CFN99062	Tetrahydroxysqualene	1043629-23-7	474.7	C₃₀H₅₀O₄