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Vallesiachotamine
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Product Name Vallesiachotamine
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CAS No.: 5523-37-5
Catalog No.: CFN92640
Molecular Formula: C21H22N2O3
Molecular Weight: 350.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Uncaria rhynchophylla
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Vallesiachotamine exhibits important cytotoxicity toward human melanoma cells by apoptosis and necrosis.
In vitro:
Arch Pharm Res. 2012 Mar;35(3):565-71.
In vitro antiproliferative effects of the indole alkaloid vallesiachotamine on human melanoma cells.[Pubmed: 22477204]
Vallesiachotamine was isolated from the leaves of Palicourea rigida (Rubiaceae) collected in the Brazilian Cerrado.
METHODS AND RESULTS:
The structure was determined by spectroscopic methods, mainly 1D- and 2D-NMR and its biological activities were investigated on cultured human (SK-MEL-37) melanoma cells. In vitro cytotoxicity was evaluated by the 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The inhibitory concentration (IC(50)) was 14.7 ± 1.2 μM for 24 h of drug exposure. Flow cytometry analysis revealed that Vallesiachotamine induced G0/G1 arrest and increased the proportion of sub-G1 hypodiploid cells (at 11 μM and 22 μM) and this effect was not dependent on time of incubation. At these concentrations, a typical ladder was observed by agarose gel electrophoresis of the extracted DNA. Treatment of cells with 50 μM Vallesiachotamine for 24 h caused extensive cytotoxicity and necrosis.
CONCLUSIONS:
Our results demonstrated that the indole alkaloid Vallesiachotamine exhibited important cytotoxicity toward human melanoma cells and that apoptosis and necrosis might be responsible for the observed events.
Vallesiachotamine Description
Source: The herbs of Uncaria rhynchophylla
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8539 mL 14.2694 mL 28.5388 mL 57.0776 mL 71.347 mL
5 mM 0.5708 mL 2.8539 mL 5.7078 mL 11.4155 mL 14.2694 mL
10 mM 0.2854 mL 1.4269 mL 2.8539 mL 5.7078 mL 7.1347 mL
50 mM 0.0571 mL 0.2854 mL 0.5708 mL 1.1416 mL 1.4269 mL
100 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.5708 mL 0.7135 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Planta Med. 1983 Feb;47(2):83-6.
Alkaloids from Tabernaemontana psorocarpa.[Pubmed: 17405098 ]
The isolation of the alkaloids from two different samples of stem bark of Tabernaemontana psorocarpa is described.
METHODS AND RESULTS:
Both samples contained 16-epi-isositsirikine as the major alkaloid but differed from each other in the number and quantity of the other alkaloids. The following minor alkaloids were identified: 12-methoxy-14,15-dehydro-vincamine, Vallesiachotamine, isoVallesiachotamine, tetrahydroalstonine, coronaridine and voacangine.
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