(-)-Variabilin | CAS:370102-93-5 | Manufacturer ChemFaces

(-)-Variabilin

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Description:

Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro and shows anti-inflammatory activity after topical or p.o. administration to mice.

Targets:

Phospholipase (e.g. PLA) | Immunology & Inflammation related

In vitro:

J. Biol. Chem., 1996, 271(30):17785-90.

Variabilin, a Novel RGD-containing Antagonist of Glycoprotein IIb-IIIa and Platelet Aggregation Inhibitor from the Hard Tick Dermacentor variabilis*[Reference: WebLink]

METHODS AND RESULTS:
A novel inhibitor of human platelet aggregation, named variabilin, was isolated from salivary glands of the hard tick Dermacentor variabilis using a combination of gel filtration and high pressure liquid chromatography. Variabilin was a potent antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3. Amino acid sequence analysis by Edman degradation revealed that it has 47 residues, with a molecular weight of 4968.5. Like many other naturally occurring antagonists of GPIIb-IIIa, variabilin contains the RGD (Arg-Gly-Asp) motif. However, unlike the RGD-containing antagonists of GPIIb-IIIa, the RGD sequence of variabilin is not positioned in a loop bracketed by cysteine residues.
CONCLUSIONS:
It has little sequence homology to the other known naturally occurring antagonists of GPIIb-IIIa, including the disintegrins from snakes, decorsin and ornatin from leeches, and disagregin from soft ticks. Variabilin is the first RGD-containing antagonist isolated from ticks.

(-)-Variabilin Description

Source:	The roots of Angelica sinensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	(-)-Variabilin
Price:
CAS No.:	370102-93-5
Catalog No.:	CFN97945
Molecular Formula:	C₁₇H₁₆O₅
Molecular Weight:	300.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Angelica sinensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Inhibitors Compound Library Anti-platelet aggregation Compound Library Markers Compound Library Antagonists Compound Library Antimicrobial Compound Library Flavonoids Compound Library Phospholipase (e.g. PLA) Inhibitor Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.33 mL	16.65 mL	33.3 mL	66.6001 mL	83.2501 mL
5 mM	0.666 mL	3.33 mL	6.66 mL	13.32 mL	16.65 mL
10 mM	0.333 mL	1.665 mL	3.33 mL	6.66 mL	8.325 mL
50 mM	0.0666 mL	0.333 mL	0.666 mL	1.332 mL	1.665 mL
100 mM	0.0333 mL	0.1665 mL	0.333 mL	0.666 mL	0.8325 mL

CFN96002	1,11b-Dihydro-11b-hydroxymedicarpin	210537-04-5	288.3	C₁₆H₁₆O₅
CFN96003	1,11b-Dihydro-11b-hydroxymaackiain	210537-05-6	302.3	C₁₆H₁₄O₆
CFN89484	Pterocarpadiol D	2055882-23-8	304.29	C₁₆H₁₆O₆
CFN89483	Pterocarpadiol C	2055882-22-7	318.27	C₁₆H₁₄O₇
CFN89481	Pterocarpadiol B	2055882-20-5	302.27	C₁₆H₁₄O₆
CFN89482	Pterocarpadiol A	2055882-21-6	316.26	C₁₆H₁₂O₇
CFN98711	Brazilin	474-07-7	286.3	C₁₆H₁₄O₅
CFN96490	Hematoxylin	517-28-2	302.28	C₁₆H₁₄O₆
CFN97043	3,9-Dihydroxypterocarpan	61135-91-9	256.3	C₁₅H₁₂O₄
CFN97226	Isomedicarpin	74560-05-7	270.3	C₁₆H₁₄O₄