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    CAS No. 1857-30-3 Price
    Catalog No.CFN96450Purity>=98%
    Molecular Weight217.27Type of CompoundAlkaloids
    FormulaC13H15NO2Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Viroallosecurinine Description
    Source: The roots of Securinega virosa
    Biological Activity or Inhibitors: 1. Virosecurinine and viroallosecurinine were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa.
    2. Viroallosecurinine exhibits a MIC of 0.48 micrograms/ml for Pseudomonas aeruginosa and Staphylococcus aureus.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.6026 mL 23.0128 mL 46.0257 mL 92.0514 mL 115.0642 mL
    5 mM 0.9205 mL 4.6026 mL 9.2051 mL 18.4103 mL 23.0128 mL
    10 mM 0.4603 mL 2.3013 mL 4.6026 mL 9.2051 mL 11.5064 mL
    50 mM 0.0921 mL 0.4603 mL 0.9205 mL 1.841 mL 2.3013 mL
    100 mM 0.046 mL 0.2301 mL 0.4603 mL 0.9205 mL 1.1506 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Viroallosecurinine References Information
    Citation [1]

    Nat Prod Res. 2007 Mar;21(3):234-42.

    Callus of Securinega suffruticosa, a cell line accumulates dextro Securinega alkaloids.[Pubmed: 17365714 ]
    Investigations on callus cultures of Securinega suffruticosa indicated that the cell line of S. suffruticosa callus was able to accumulate four known Securinega alkaloids with dextro rotation but not levo rotation as reported before: virosecurinine (1), Viroallosecurinine (2), 14,15-dihydrovirosecurinine (3) and ent-phyllanthidine (4). Time course studies on the growth of callus cultures were carried out. The effects of different plant growth regulators, sucrose concentrations on callus growth and virosecurinine production were also reported.
    Citation [2]

    J Pharm Sci. 1991 Apr;80(4):325-7.

    Cytotoxic principles of Securinega virosa: virosecurinine and viroallosecurinine and related derivatives.[Pubmed: 1865332]
    Virosecurinine (1) and Viroallosecurinine (2) were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. A comparison of the cytotoxicity of 1 and several of its derivatives indicates that an alpha,beta- and a gamma,delta-unsaturated lactone located in a strained ring system, such as rings -B, -C, and -D of 1, is structurally required for significant cytotoxicity.
    Citation [3]

    J Ethnopharmacol. 1990 Feb;28(1):129-33.

    Antibacterial activity of the leaves of Phyllanthus discoideus.[Pubmed: 2156112]
    The lyophilized aqueous extract (LWE) from the leaves of Phyllanthus discoideus was found to show an antibacterial activity. The alkaloid fraction obtained from LWE inhibited the growth of Escherichia coli and Enterococcus faecium (MIC = 1.6 mg/ml), Pseudomonas aeruginosa (MIC = 0.78 mg/ml), Staphylococcus aureus and Mycobacterium smegmatis (MIC = 0.2 mg/ml). Among the alkaloids identified, Viroallosecurinine and securinine showed a high activity. Viroallosecurinine exhibited a MIC of 0.48 micrograms/ml for Ps. aeruginosa and Staph. aureus. This alkaloid is bactericidal since the yields of MIC/MBC were less than 1. The MIC of securinine was 0.500 mg/ml for E. coli, Staph. aureus and Myc. smegmatis. These effects of Phyllanthus discoideus leaf extracts support some of the local uses of the plant in traditional therapy.