Science | Nature | Cell | View More
Natural Products
Vomicine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Vomicine
Price:
CAS No.: 125-15-5
Catalog No.: CFN96442
Molecular Formula: C22H24N2O4
Molecular Weight: 380.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The seeds of Strychnos nux-vomica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Ioannina (Greece)
  • National Chung Hsing University (Taiwan)
  • Monash University Sunway Campus (Malaysia)
  • Anna University (India)
  • Washington State University (USA)
  • University of Parma (Italy)
  • University of Indonesia (Indonesia)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Texas A&M University (USA)
  • Uniwersytet JagielloĊ„ski w Kra... (Poland)
  • Institute of Pathophysiology Me... (Austria)
  • More...
Package
Featured Products
Succinic acid

Catalog No: CFN99100
CAS No: 110-15-6
Price: $30/20mg
Pyrogallol

Catalog No: CFN97443
CAS No: 87-66-1
Price: $30/20mg
Humulone

Catalog No: CFN90541
CAS No: 26472-41-3
Price: $ / mg
Ginsenoside Rd

Catalog No: CFN99975
CAS No: 52705-93-8
Price: $30/20mg
Madecassic acid

Catalog No: CFN99914
CAS No: 18449-41-7
Price: $30/20mg
Deoxypodophyllotoxin

Catalog No: CFN99888
CAS No: 19186-35-7
Price: $268/10mg
Isoescin IA

Catalog No: CFN90932
CAS No: 219944-39-5
Price: $238/20mg
Isovitexin

Catalog No: CFN98620
CAS No: 38953-85-4
Price: $50/20mg
Dehydroevodiamine

Catalog No: CFN90944
CAS No: 67909-49-3
Price: $50/20mg
Soyasaponin Bb

Catalog No: CFN90456
CAS No: 51330-27-9
Price: $138/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Vomicine is a natural product from Strychnos nux-vomica, the S. nux-vomica extracts show antihyperglycemic activity in experimental animals.
In vitro:
Planta Med. 2000 Apr;66(3):262-9.
New antimalarial and cytotoxic sungucine derivatives from Strychnos icaja roots.[Pubmed: 10821054]

METHODS AND RESULTS:
Reinvestigation of Strychnos icaja Baillon resulted in the isolation of Vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy-isosungucine (10). They were identified by detailed spectroscopic methods. The complete 1H- and 13C-NMR study of sungucine was also realized. Some of these compounds were highly active against Plasmodium falciparum in vitro and more particularly against the chloroquine-resistant strain.
CONCLUSIONS:
Compound 10 showed a selective antiplasmodial activity, with > 100-fold greater toxicity towards Plasmodium falciparum, relative to cultured human cancer cells (KB and HeLa lines) or fibroblasts (WI38).
Planta Med. 2012 Mar;78(4):377-82.
Antiplasmodial alkaloids from the stem bark of Strychnos malacoclados.[Pubmed: 22193980 ]
From the stem bark of Strychnos malacoclados, one new bisindole alkaloid, 3-hydroxylongicaudatine Y (1), was isolated along with the known alkaloids Vomicine (2), bisnordihydrotoxiferine (3), divarine (4), longicaudatine (5), longicaudatine Y (6), and longicaudatine F (7).
METHODS AND RESULTS:
All the compounds were tested for their antimalarial activity against the chloroquine-sensitive 3D7 and -resistant W2 strains of Plasmodium falciparum. Longicaudatine was the most active compound with IC₅₀ values of 0.682 and 0.573 µM, respectively. The activity of compounds 1, 3, 4, 6, and 7 against the two strains ranged from 1.191 to 6.220 µM and 0.573 to 21.848 µM, respectively. Vomicine (2), the only monomer isolated, was inactive. The alkaloids of the longicaudatine-type ( 1, 5-7) were more active than those of the caracurine-type (3- 4). The presence of the ether bridge in the molecule seems to increase the antiplasmodial activity. Compounds 1, 5, and 7 were tested against the WI-38 human fibroblast cell line. Longicaudatine was the most cytotoxic compound with an IC₅₀ of 2.721 µM.
CONCLUSIONS:
Longicaudatine F was 40-46 times more active against the two strains of P. falciparum than against the human fibroblasts and was thus considered as the more selective alkaloid. The structures of the compounds were determined based on the analysis of their spectral data.
In vivo:
J Ayurveda Integr Med. 2012 Apr;3(2):80-4.
Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity.[Pubmed: 22707864 ]
Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents. Minor alkaloids present in the seeds are protostrychnine, Vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine, chlorogenic acid, and a glycoside. Seeds are used traditionally to treat diabetes, asthma, aphrodisiac and to improve appetite.The present study was aimed to evaluate the various pharmacognostical characters and antidiabetic activity of S. nux-vomica seed.
METHODS AND RESULTS:
Pharmacognostical characters were performed as per the WHO guideline. Extraction was carried out in petroleum ether, chloroform, alcohol, hydroalcoholic, aqueous, and phytochemical constituents present in extracts were detected by different chemical tests. Among these extracts hydroalcoholic, aqueous extracts were evaluated for antidiabetic activity on the basis of extractive yield and phytoconstituents, in alloxan-induced diabetic rats using gliclazide as standard. Various analytical values of S. nux-vomica extract were established. Phytoconstituents present in S. nux-vomica extracts were detected.
CONCLUSIONS:
S. nux-vomica extracts show antihyperglycemic activity in experimental animals.
Vomicine Description
Source: The seeds of Strychnos nux-vomica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
10-O-trans-p-Feruloylscandoside

Catalog No: CFN95392
CAS No: 1428268-72-7
Price: $318/10mg
Lathyranoic acid A

Catalog No: CFN95325
CAS No: 850560-44-0
Price: $318/5mg
Isoengeletin

Catalog No: CFN95284
CAS No: 30987-58-7
Price: $318/5mg
2''-O-acetylsaikosaponin A

Catalog No: CFN95085
CAS No: 102934-42-9
Price: $318/5mg
Cannabisin B

Catalog No: CFN95268
CAS No: 144506-17-2
Price: $413/5mg
Ganoderenic acid K

Catalog No: CFN95469
CAS No: 942950-94-9
Price: $318/10mg
Rosmarinyl glucoside

Catalog No: CFN95297
CAS No: 910028-78-3
Price: $413/5mg
Toddalolactone 3'-O-methyl ether (...

Catalog No: CFN95372
CAS No: 143614-35-1
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6288 mL 13.1441 mL 26.2881 mL 52.5762 mL 65.7203 mL
5 mM 0.5258 mL 2.6288 mL 5.2576 mL 10.5152 mL 13.1441 mL
10 mM 0.2629 mL 1.3144 mL 2.6288 mL 5.2576 mL 6.572 mL
50 mM 0.0526 mL 0.2629 mL 0.5258 mL 1.0515 mL 1.3144 mL
100 mM 0.0263 mL 0.1314 mL 0.2629 mL 0.5258 mL 0.6572 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Succinic acid

Catalog No: CFN99100
CAS No: 110-15-6
Price: $30/20mg
Pyrogallol

Catalog No: CFN97443
CAS No: 87-66-1
Price: $30/20mg
Humulone

Catalog No: CFN90541
CAS No: 26472-41-3
Price: $ / mg
Ginsenoside Rd

Catalog No: CFN99975
CAS No: 52705-93-8
Price: $30/20mg
Madecassic acid

Catalog No: CFN99914
CAS No: 18449-41-7
Price: $30/20mg
Deoxypodophyllotoxin

Catalog No: CFN99888
CAS No: 19186-35-7
Price: $268/10mg
Isoescin IA

Catalog No: CFN90932
CAS No: 219944-39-5
Price: $238/20mg
Isovitexin

Catalog No: CFN98620
CAS No: 38953-85-4
Price: $50/20mg
Dehydroevodiamine

Catalog No: CFN90944
CAS No: 67909-49-3
Price: $50/20mg
Soyasaponin Bb

Catalog No: CFN90456
CAS No: 51330-27-9
Price: $138/20mg
Tags: buy Vomicine | Vomicine supplier | purchase Vomicine | Vomicine cost | Vomicine manufacturer | order Vomicine | Vomicine distributor