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Worenine
Worenine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Worenine
Price:
CAS No.: 38763-29-0
Catalog No.: CFN90415
Molecular Formula: C20H16NO4+
Molecular Weight: 334.11 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Cryst.
Source: The roots of Coptis chinensis Franch.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Reference standards.
In vivo:
J Pharm Biomed Anal. 2010 Jan 5;51(1):236-43.
Characterization of metabolites of worenine in rat biological samples using liquid chromatography-tandem mass spectrometry.[Pubmed: 19773142]
The in vivo and in vitro metabolites of Worenine in rat were identified or characterized using a specific and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method.
METHODS AND RESULTS:
In vivo samples including rat urine, feces, and plasma samples were collected after ingestion of 25 mg/kg Worenine to healthy rats. The in vivo and in vitro samples were cleaned up by a solid-phase extraction procedure (C18 cartridges) and a liquid-liquid extraction procedure, respectively. Then these pretreated samples were injected into a reversed-phase C18 column with mobile phase of methanol-ammonium acetate (2mM, adjusted to pH 3.5 with formic acid) (60:40, v/v) and detected by an on-line MS/MS system. As a result, at least twenty-seven metabolites and the parent medicine were found in rat urine after ingestion of Worenine. Seven metabolites and the parent medicine were identified or characterized in rat feces. Three metabolites and the parent medicine were detected in rat plasma. One metabolite was found in the rat intestinal flora incubation mixture, and three metabolites were characterized in the homogenized liver incubation mixture.
CONCLUSIONS:
The main phase I metabolism of Worenine in rat was dehydrogenization, hydrogenation, hydroxylation, and demethylene reactions, and that of phase II was sulfation and glucuronidation.
Worenine Description
Source: The roots of Coptis chinensis Franch.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.993 mL 14.9651 mL 29.9303 mL 59.8605 mL 74.8257 mL
5 mM 0.5986 mL 2.993 mL 5.9861 mL 11.9721 mL 14.9651 mL
10 mM 0.2993 mL 1.4965 mL 2.993 mL 5.9861 mL 7.4826 mL
50 mM 0.0599 mL 0.2993 mL 0.5986 mL 1.1972 mL 1.4965 mL
100 mM 0.0299 mL 0.1497 mL 0.2993 mL 0.5986 mL 0.7483 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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Nicotiflorin

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CAS No: 17650-84-9
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