1. (S)-10-Hydroxycamptothecin (OPT), an analog of camptothecin (CPT), was found to inhibit the growth of the mouse hepatoma BW7756, when given at 1.0 mg/kg/day for 14 days; in spite of the narrow range of the effective dose of this drug against mouse hepatoma BW7756, the use of OPT in combination with other antitumor agents may be useful in primary hepatoma or liver metastases in view of its low toxicity towards host liver.
2. (S)-10-Hydroxycamptothecin, as an inhibitor of the growth of P388 leukemia in mice, is as potent as the parent compound camptothecin (CPT).
1. (Z)-Butylidenephthalide has antitumor effect, can effectively inhibit the tumor growth in the glioma.
1. 1,2,3,4,6-Pentagalloylglucose and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities.
2. 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose (PGG) possesses potent anti-proliferative and anti-invasive effects, it also has inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity.
3. PGG may serve as a model for the development of new types of anti-diabetic and anti-metabolic syndrome therapeutics.
4. 1,2,3,4,6-Penta- O -galloyl-β- d -glucose has vasodilatory and anti-inflammatory effects, it dilates vascular smooth muscle and suppresses the vascular inflammatory process via endothelium-dependent nitric oxide (NO)/cGMP signaling.
5. 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose can decrease the level of extracellular hepatitis B virus (HBV) (IC50, 1.0 microg/ml) in a dose-dependent manner, it also can reduce the HBsAg level by 25% at a concentration of 4 microg/ml; the gallate structure of PGG may play a critical role in the inhibition of anti-HBV activity, suggests that PGG could be a candidate for developing an anti-HBV agent.
6. 1,2,3,4,6-Penta-O-galloyl-β-D-glucose has anti-parasitic activity, displays an EC50 value of 67 μM, at least 6.6-fold more effective than the standard drug benznidazole against trypomastigote forms of T. cruzi.
1. 1,2,3,6-Tetragalloylglucose has antioxidative activity.
2. 1,2,3,6-Tetragalloylglucose shows the most potent anticomplement activity (IC(50), 34 microM).
1. 1,2-Benzenediol(catechol) is used as 5% aq. soln. for photometric detn. of Nb, Os, Ta, Ti, W, complexing agent of some metals (e.g. Al, Ti) (anionic complexes associated with basic dyes).
2. 1,2-Dihydroxybenzene can induce spontaneous convulsive activity in the anaesthetized mouse.
3. 1,2-Dihydroxybenzene can produce myoclonic jerks in the rat.
1. 1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
1. 1,3-Dicaffeoylquinic acid exhibits antioxidant properties, probably through the involvement of a direct scavenging effect on several free radicals.
2. 1,3-Dicaffeoylquinic acid and 1,5-dicaffeoylquinic acid, ginkgolic acids (15 : 1) and (17 : 1), and epicatechin can significantly inhibit hOAT3 transport under similar conditions.
1. 1,4-Dicaffeoylquinic acid has antioxidant activity.
2. 1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentrations.
1. 1,5-Dicaffeoylquinic acid has neuroprotective effects, it can prevent Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax.
2. 1,5-Dicaffeoylquinic acid has antioxidant activity, and is stronger than that of ascorbic acid.
3. 1,5-Dicaffeoylquinic acid has protective effects against MPP~+ induces neurotoxicity of PC12 Cells, it (50 umol/L) pretreatment can inhibit the MPP+-induced up-regulation of the expression of α-synuclein mRNA and protein.
4. 1, 5-Dicaffeoylquinic acid can mediate glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes.
1. 10-Gingerol has anti-neuroinflammatory capacity.
2. 10-Gingerol effectively inhibits the growth of the oral pathogens, and inhibits exogenous ghrelin deacylation.
3. 10-Gingerol induces [Ca2+]i rise by causing Ca2+ release from the endoplasmic reticulum and Ca2+ influx from non-L-type Ca2+ channels in SW480 cancer cells.
4. 10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).