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    ChemFaces is a professional high-purity natural products manufacturer.

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    Natural Products
    Catalog No. Information
    CFN99122 1,4-Dicaffeoylquinic acid

    1. 1,4-Dicaffeoylquinic acid has antioxidant activity.
    2. 1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentrations.
    CFN99123 1,5-Dicaffeoylquinic acid

    1. 1,5-Dicaffeoylquinic acid has neuroprotective effects, it can prevent Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax.
    2. 1,5-Dicaffeoylquinic acid has antioxidant activity, and is stronger than that of ascorbic acid.
    3. 1,5-Dicaffeoylquinic acid has protective effects against MPP~+ induces neurotoxicity of PC12 Cells, it (50 umol/L) pretreatment can inhibit the MPP+-induced up-regulation of the expression of α-synuclein mRNA and protein.
    4. 1, 5-Dicaffeoylquinic acid can mediate glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes.
    CFN99132 10-Gingerol

    1. 10-Gingerol has anti-neuroinflammatory capacity.
    2. 10-Gingerol effectively inhibits the growth of the oral pathogens, and inhibits exogenous ghrelin deacylation.
    3. 10-Gingerol induces [Ca2+]i rise by causing Ca2+ release from the endoplasmic reticulum and Ca2+ influx from non-L-type Ca2+ channels in SW480 cancer cells.
    4. 10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).
    CFN99736 10-Hydroxycamptothecin

    1. 10-Hydroxycamptothecin is an indole alkaloid isolated from a Chinese tree, Camptotheca acuminata, and has a wide spectrum of anticancer activity in vitro and in vivo mainly through inhibitory effects on topoisomerase I.
    2. 10-Hydroxycamptothecine can prevent fibroblast proliferation and epidural scar adhesion after laminectomy in rats.
    3. 10-Hydroxycamptothecin has antiangiogenic potential.
    CFN92300 10-Shogaol

    1. 10-Shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
    2. 8- and 10-Shogaol have similar metabolic profiles to [6]-shogaol and exhibit similar toxicity toward human colon cancer cells.
    CFN90366 11-Hydroxy-sugiol

    CFN90152 11-Keto-beta-boswellic acid

    1. 11-Keto-beta-boswellic acid possesses significant anti-inflammatory activity.
    2. 11-Keto-beta-boswellic acid exerts multi-focal action in cancer cells while it required 10-fold higher the concentration to produce cytotoxicity in normal human PBMC and gingival cell line, and therefore, may find usefulness in the management of human leukemia.
    3. 11-Keto-beta-boswellic acid , a novel Nrf2 activator, it can increase the Nrf2 and HO-1 expression, which provides protection against oxygen and glucose deprivation (OGD)-induced oxidative insult.
    4. 11-Keto-beta-boswellic acid reveals anti-tumoral activity against both ascitic and solid murine tumor models, it induces apoptosis in HL-60 cells due to the inhibition of topoisomerases I and II.
    5. 11-Keto-beta-boswellic acid derived amides and monodesmosidic saponins induce apoptosis in breast and cervical cancers cells.
    6. 11-Keto-beta-boswellic acid is a selective 5-lipoxygenase (5-LOX) inhibitor, it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenase.
    CFN96345 11-O-Galloylbergenin

    1. 11-O-Galloylbergenin shows significant analgesic activity at doses of 20 and 40 mg/kg against formalin test in rats, and it exhibits significant anti-inflammatory activity in carrageenan-induced paw edema model at doses of 10, 20 and 30 mg/kg.
    2. 11-O-Galloylbergenin shows good antioxidant and antiplasmodial activities, the EC50 values are 7.45±0.2 ug/mL and 5.39±0.28 ug/mL in DPPH antioxidant assay and reducing power assay respectively, while IC50 value for antiplasmodial assay is less than 2.5 uM.
    3. 11-O-Galloylbergenin shows significant urease inhibitory potential with IC50 value of 38.6±1.5 uM.
    CFN90365 11-Oxo-mogroside V

    1. 11-Oxo-mogroside V , a sweet element of Siraitia grosvenori (SG) extract, provides the anti-oxidative property of SG which might reduce the atherogenic potential of low-density lipoprotein(LDL).
    2. 11-Oxo-mogroside V exhibits the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
    3. 11-Oxo-mogroside V exhibits a remarkable inhibitory effect on *OH-induced DNA damage with EC50 = 3.09 microg/ml.
    CFN89377 12-O-Methylcarnosic acid

    1. 12-O-Methylcarnosic acid is effective preventing gastric lesions.
    2. 12-O-Methylcarnosic acid has antioxidant activity.
    3. 12-O-Methylcarnosic acid can suppress melanin production with downregulation of tyrosinase expression in HMV-II melanoma cells.
    4. 12-O-Methylcarnosic acid is able to significantly activate peroxisome proliferator-activated receptor (PPAR)γ, it may have anti-diabetic activity.