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    Natural Products
    Catalog No. Information
    CFN99995 2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside

    1. 2,3,5,4'-Tetrahydroxyldiphenylethylene-2-O-glucoside(TSG) blocks the proliferation of PASMCs induced by PDGF-BB through arresting the cell cycle in G0 / G1 phase, indicates that TSG suppress PDGF-BB-induced PASMCs proliferation is associated with an inhibition of AKT / GSK3β signaling pathways.
    2. TSG not only prevents over-expression of α-synuclein at an early stage, but also reverses the increased expression of α-synuclein and inhibits the aggregation at the late stage of Tg mice, it may have potential to the prevention and treatment of Alzheimer's diseases.
    3. TGS, emodin and physcion have the lipid regulation activity to an overall synergy.
    CFN98170 20(R)-Ginsenoside Rg3

    1. 20(R)-Ginsenoside Rg3 has anti-aging and antifatigue activities.
    2. 20(R)-Ginsenoside Rg3 shows significant effect on the differential expression of cell signaling genes and other related genes in human lung cell line A549.
    3. 20(R)-Ginsenoside Rg3 and PEG-PLGA-Rg3 nanoparticles can supress the tumor angiogenesis in vivo,which is perhaps related to the inhibition of expression in MMP-9,HIF-1α,VEGF,IL-1,IL-6 and TNF-α.
    4. 20(R)-Ginsenoside Rg3 has anticarcinogenic effects on Induced Hepatocellular Carcinoma in Rats.
    5. 20(R)-Ginsenoside Rg3 elicits a significant inhibition of in vitro cell adhesion and invasion of U87 cells, is attributed to its decreasing the enzymatic activity of MMP-2.
    6. 20(R)-Ginsenoside Rg3 can restrain A549/DDP cell invasion and metastasis,and it may have relationship with the upregulation of nm23;Rg3 can enhance the A549/DDP cell chemosensitivity to cisplatin,and it may have relationship with the upregulation of caspase-3 and the cell membrane lipid fluidity decreased.
    7. 20(R)-ginsenoside Rg3 exerts a neuroprotective effect on a rat model of transient focal cerebral ischemia.
    CFN90340 20(R)-Ginsenoside Rh2

    1. 20(R)-Ginsenoside Rh2, a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory.
    2. 20(R)-Ginsenoside Rh2 has a significant inhibitory effect on the proliferation.
    3. 20(R)-Ginsenoside Rh2 has anti-inflammatory and antioxidative activities.
    4. 20(R)-Ginsenoside Rh2 shows selective osteoclastgenesis inhibitory activity without any cytotoxicity up to 100 microM.
    5. 20 (R)-ginsenoside Rh2 and 20(S)-ginsenoside Rh2 have anticancer effects and can increase inchoate apoptotic rate, reduce apoptotic rate significantly, enhance the activity of caspase-3 and induces apoptosis in human lung adenocarcinoma A549 cells.
    CFN99971 20(S)-Ginsenoside Rh2

    1. Ginsenoside Rh2 can suppress RANKL-induced osteoclast differentiation in vitro and in vivo through the regulation of c-Fos and NFATc1 expressions, not excluding the involvement of NF-κB and ERK, it is also suggested to be developed as a therapeutic drug for prevention and treatment of osteoporosis.
    2. Ginsenoside Rh2 has antitumor, antidiabetic, antiallergic, and anti-inflammatory effects.
    3. Ginsenoside Rh2 potently protects ischemia-reperfusion brain injury, also inhibits prostaglandin-E_2 synthesis in lipopolysaccharide-stimulated RAW264.7 cells, suggests it can improve ischemic brain injury.
    4. Ginsenoside Rh2 potently reverses memory impairment caused by scopolamine, it may improve learning deficits, also have the memory-enhancing effects of RGB.
    5. Ginsenoside Rh2 can suppress growth of uterine leiomyoma in vitro and in vivo and may regulate ERα/c-Src/p38 MAPK activity.
    6. Ginsenoside Rh2 can inhibit the tendency of apoptosis, and reverse the impaired β-cell growth potential by modulating Akt/Foxo1/PDX-1 signaling pathway and regulating cell cycle proteins, suggests its therapeutic potential in the treatment of diabetes.
    CFN98873 20-Hydroxyecdysone

    1. 20-Hydroxyecdysone slowly reduces food consumption and then indirectly induces a state of starvation resulting in the elevation of the mRNA levels of InR , IRS , PI3K110 , and PDK in the Bombyx fat body during molting and pupation, and 20-hydroxyecdysone inhibits innate immunity in the fat body during Bombyx postembryonic development.
    2. 20-Hydroxyecdysone as ingredients in nutritional supplements for various sports, particularly bodybuilding.
    3. 20-Hydroxyecdysone induces autophagy and caspase activity, predominantly transduced by E93 in the remodeling fat body of Drosophila.
    4. 20-Hydroxyecdysone (via GPCR activation and calcium signaling) activates CaMKII phosphorylation and nuclear translocation, which regulate USP1 lysine acetylation to form an EcRB1-USP1 complex for 20E response gene transcription.
    5. 20-Hydroxyecdysone acts as both a positive and a negative regulator of EDG transcription, sequences in the promoter regions of two of the EDGs are similar to an ecdysone response element and may play a role in negative regulation.
    CFN90412 20R-Ginsenoside Rg2

    1. Ginsenoside Rg2 can protect H9c2 cells against H2O2- induced injury through its actions of anti-oxidant and anti-apoptosis.
    2. Ginsenoside Rg2 suppresses the hepatic glucose production via AMPK-induced phosphorylation of GSK3βand induction of SHP gene expression, it may have a therapeutic potential for type 2 diabetic patients.
    3. 20R-Ginsenoside Rg2 inhibits the cytokine interleukin 1 alpha (IL-1α)-induced reduction in gap junction-mediated intercellular communication (GJIC).
    CFN99496 24-Methylenecycloartan-3-ol

    1. 24-Methylenecycloartan-3-ol and methyl caffeate show weak activity against Staphylococcus aureus and Escherichia coli.
    CFN93572 25R-Inokosterone

    1. 25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.
    CFN93571 25S-Inokosterone

    1. 25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.
    CFN97032 2-Hydroxy-1,8-cineole

    1. 2-endo-Hydroxy-1,8-cineole shows antimicrobial and bactericidal activities against against test bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescens) .