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    Natural Products
    Catalog No. Information
    CFN99810 2-Hydroxy-3-methylanthraquinone

    1. 2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activation mediated apoptotic induction.
    2. 2-Hydroxy-3-methylanthraquinone enhances apoptosis of THP-1 cells, in part, through activation of Fas/FasL, DR4 and TRAIL; triggers caspase-8 activation mediated apoptotic induction.
    CFN99257 2'-Hydroxygenistein

    1. 2'-Hydroxygenistein has antifungal activity, dimerization of it causes a remarkable increase of antifungal activity.
    2. 2'-Hydroxygenistein exhibits greater antiproliferative effects in MCF-7 human breast cancer cells than does genistein, suggest that 2'-hydroxylation of genistein can enhance its antioxidant activity and cell cytotoxicity in MCF-7 human breast cancer cells.
    3. 2'-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B.
    CFN97950 2-Hydroxynaringenin

    1. The recombinant protein exhibits high FNS I activity catalyzing the conversion of naringenin to apigenin and 2-Hydroxynaringenin.
    CFN90576 3,29-Dibenzoyl karounitriol

    CFN95021 3,3',4',5,6,7,8-heptamethoxyflavone

    CFN90238 3,4,5-Tricaffeoylquinic acid

    1. 3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-ĸB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.
    2. 3,4,5-Tricaffeoylquinic acid may attenuate the proteasome inhibitor-induced programmed cell death in PC12 cells by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways, the effect be attributed to its inhibitory effect on the formation of reactive oxygen species and depletion of GSH.
    CFN99450 3,4-Dihydroxybenzaldehyde

    1. 3,4-Dihydroxybenzaldehyde has been shown to inhibit the growth of Gloeosporium musarum, a fungus which causes ripe fruit rot in the banana.
    2. 3,4-Dihydroxybenzaldehyde can inhibit oxidative DNA damage and apoptosis via its antioxidant activity.
    3. 3,4-Dihydroxybenzaldehyde inhibits the phosphotransferase activity of CKII with IC(50) of about 783 microM, it may function by inhibiting oncogenic disease, at least in part, through the inhibition of CKII activity.
    4. 3,4-Dihydroxybenzaldehyde inhibits the H2O2-induced apoptosis of granulosa cells, promotes estradiol secretion in granulosa cells and enhanced the mRNA expression levels of steroidogenic factor 1, a promoter of key steroidogenic enzymes.
    5. 3,4-Dihydroxybenzaldehyde has tyronase inhibitory effect.
    CFN97568 3,4-Dihydroxybenzoic acid

    1. 3,4-Dihydroxybenzoic acid exhibits scavenging actions against the 1,1-diphenyl-2-picrylhydrazyl radical, the superoxide anion, and the hydroxyl radical.
    2. 3,4-Dihydroxybenzoic acid isolates from a green alga protects human keratinocytes against UVB-induced oxidative stress and apoptosis.
    3. 3,4-Dihydroxybenzoic acid has been shown to prevent carcinogenesis or antitumor growth in vivo, it has apoptotic effect on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation.
    4. 3,4-Dihydroxybenzoic acid can prevent Abeta (25-35)-induced neuronal cell damage by interfering with the increase of [Ca(2+)](c), and then by inhibiting glutamate release, generation of ROS and caspase-3 activity.
    5. 3,4-Dihydroxybenzoic acid has protection against Adriamycin cytotoxicity and inhibition of DNA topoisomerase II activity.
    6. 3,4-Dihydroxybenzoic acid has nematicidal activity against Meloidogyne incognita.
    7. 3,4-Dihydroxybenzoic acid shows significant antioxidant using DPPH and antimicrobial activities.
    CFN99673 3',5,5',7-Tetrahydroxyflavanone

    1. 5,7,3',5'-Tetrahydroxyflavanone has inhibitory effects on HIV-1 reverse transcriptase (RT)-associated RNase H function, it may have antiviral activity against HIV-1.
    2. 5,7,3',5'-Tetrahydroxyflavanone has anti-inflammatory properties, it can inhibit nitric oxide (NO) production with IC50 values of 18.5 uM, the inhibitory effect is accompanied by dose-dependent decreases in LPS-induced nitric oxide synthase (iNOS) in RAW 264.7 cells.
    CFN90578 3,6'-Disinapoyl sucrose

    1. 3,6'-Disinapoyl sucrose has neuroprotective effect and antidepressive activity in rats, at least in part, by increasing expression of cyclic AMP response element (CRE)-binding protein (CREB) and its downstream target protein, brain-derived neurotrophic factor (BDNF).
    2. Treatment with 3,6'-Disinapoyl sucrose (0.6, 6, and 60 μmol/L) increases cell viability dose dependently, inhibits LDH release, and attenuated apoptosis. The mechanisms by which 3,6'-Disinapoyl sucrose protect neuron cells from glutamate-induced excitotoxicity include the downregulation of proapoptotic gene Bax and the upregulation of antiapoptotic gene Bcl-2.