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    Natural Products
    Catalog No. Information
    CFN92864 3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol

    1. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol, one toxic terpenoid from raw Gansui.
    2. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships .
    3. 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol and 3-O-(2'E,4'Z)-decadienoylingenol show the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball.
    4. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol induces the cytotoxicity of intestinal epithelial cells of rats (IEC-6 cells) depends on induction of cell apoptosis via mitochondrial pathway and cell cycle arrest.
    5. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol, kansuinine B and kansuinine A can markedly promote SPL proliferation and NO production by PMphi at concentrations from 0.78 to 12.50 microg/mL, hence the they are believed to be important proinflammatory components of the roots of E. kansui.
    CFN90531 3-O-Acetyl-11-keto-beta-boswellic acid

    1. 3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(50) of 1.5 m muM.
    CFN90530 3-O-Acetyl-beta-boswellic acid

    1. 3-O-Acetyl-beta-boswellic acid has antitumor activity.
    2. 3-O-Acetyl-beta-boswellic acid inhibits synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner with IC50 values ranging from 0.6 to 7.1 microM.
    CFN98668 3-O-Acetyloleanolic acid

    1. 3-O-Acetyloleanolic acid inhibits proliferation, migration and tube formation of umbilical vein endothelial cells (HUVECs) in a dose-dependent manner; it exhibits anti-angiogenic effects and induces in HUVECs and suggests that it has a potential use for suppression of the stimulated by angiogenesis.
    2. 3-O-Acetyloleanolic acid has inhibition of angiopoietin-1-induced angiogenesis and lymphangiogenesis, it can inhibit VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral squamous cell carcinoma animal model.
    3. 3-O-Acetyloleanolic acid induces apoptosis in HCT-116 cells mediated by an extrinsic apoptosis signaling cascade via up-regulation of DR5.
    4. 3-O-Acetyloleanolic acid shows a significant decrease in the glucose level of STZ-induced diabetic rats, suggests that it has antihyperglycemic activity.
    CFN98845 3-O-Acetylpinobanksin

    CFN92573 3-O-Caffeoylquinic acid methyl ester

    CFN92393 3-O-Feruloylquinic acid

    1. 3-O-Feruloylquinic acid is a protease inhibitor.
    2. 3-O-Feruloylquinic acid exerts moderate inhibitory effect against AIV (H5N1) in vitro.
    CFN99616 3-O-Methylquercetin

    1. 3-O-Methylquercetin may exert its anti-inflammatory effect through the inhibition of iNOS DNA transcription.
    2. 3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value.
    3. 3-O-Methylquercetin inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.
    4. 3-O-Methylquercetin has both anti-inflammatory and bronchodilating effects, and has the potential for use in the treatment of asthma at a dose without affecting blood pressure.
    5. 3-O-Methylquercetin has antiviral activity.
    CFN92194 3-oxo-Olean-12-en-28-oic acid

    1. 3-oxo-Olean-12-en-28-oic acid and kulinone have cytotoxic effects, with IC50 values of 5.6-21.2 μg/mL.
    CFN92805 4,4'-Di-O-methylellagic acid

    1. 4,4'-di-O-methylellagic acid is the most effective compound in the inhibition of colon cancer cell proliferation.