1. (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucosidase (IC(50) 2.35 mM) in a noncompetitive fashion with a K(i) of 4.86 mM.
1. Precocene II is a botanically derived chemical that inhibits the production of juvenile hormone (JH) in insects.
2. Precocene II is highly toxic to adult female Rhodnius and treatment of newly emerged females prevented oogenesis.
3. Precocene II , an insect growth regulator that is structurally related to several naturally occurring carcinogenic and non-carcinogenic alkenylbenzenes, is genotoxic and produces hepatic centrolobular necrosis in rats.