1. (-)-Epicatechin gallate can effectively stimulates osteoblast differentiation, indicated by the increased expression of osteoblastic marker genes.
2. (-)-Epicatechin has the radical scavenging activity and autoxidation effect of polyphenols.
1. (-)-Epigallocatechin gallate (EGCG), a green tea polyphenol that reduce Aβ aggregation, inhibits the aggregation of tau K18ΔK280 into toxic oligomers at ten- to hundred-fold substoichiometric concentrations, thereby rescuing toxicity in neuronal model cells.
2. (-)-Epigallocatechin gallate treatment enduring to cardio protection at mitochondrial level.
1. (-)-Epigallocatechin(EGC) has prominent antiplatelet activity and blood anticoagulation in a dose-dependent manner.
1. (-)-Huperzine A is a naturally occurring potent reversible AChE inhibitor that penetrates the blood-brain barrier.
2. (-)-Huperzine A can be used as a protectIve agent against lethal dose nerve agent toxicity in guinea pigs.
3. A combination of (+) and (-)-Huperzine A offers better protection than (+)-Hup A.
1. l-isocorypalmine (l-ICP), l-ICP likely acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of cocaine addiction.
2. (-)-Isocorypalmine has significant antifungal activity.
1. Pinoresinol (PIN)can ameliorate CCl4-induced acute liver injury, and this protection is likely due to anti-oxidative activity and down-regulation of inflammatory mediators through inhibition of NF-kappaB and AP-1.
2. (+)-Pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.
3. Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels, suggests that this could be a mechanism by which PIN reduces proliferation and induces differentiation on HL60 cells.
1. Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker.
2. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers.
1. (-)-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis, may be a potential chemotherapeutic agent for the treatment of cancer.