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  • Bioactive Products
    Catalog No. Information
    CFN96175 6'-O-Galloyl paeoniflorin

    1. 6'-O-Galloylpaeoniflorin (GPF) demonstrates a significant scavenging capacity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, H2O2-generated intracellular reactive oxygen species (ROS), the superoxide anion radical (O2 -), and the hydroxyl radical (•OH); GPF also can safeguarde HaCaT keratinocytes against H2O2-provoked apoptotic cell death and attenuated oxidative macromolecular damage to DNA, lipids, and proteins; GPF exerts its cytoprotective actions in keratinocytes at least in part by decreasing the number of DNA strand breaks, the levels of 8-isoprostane (a stable end-product of lipid peroxidation), and the formation of carbonylated protein species; taken together, these results indicate that GPF may be developed as a cytoprotector against ROS-mediated oxidative stress.
    2. 6'-O-Galloylpaeoniflorin shows strong androgen receptor (AR) binding activity.