1. Agnuside has anti-arthritic activity.
2. Agnuside shows inhibition of vascular permeability and leukocyte migration in vivo.
1. Alpha-lipoic acid has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food, it is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age.
2. Alpha-lipoic acid can enhance glucose transport and utilization in different experimental and animal models, it can improve insulin sensitivity in patients with type-2 diabetes.
3. Lipoic acid is a novel treatment for Alzheimer's disease and related dementias.
4. Alpha-lipoic acid has therapeutic effects on joint inflammation and erosion in an animal model via NF-kappa B down regulation, it inhibits TNF-alpha induced NF-kappa B activation through blocking of MEKK1-MKK4-IKK signaling cascades.
1. D-Glucosamine hydrochloride is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals.
2. Fucoxanthin is an effective anti-arthritis agent through an antiinflammation mechanism, fucoxanthin may enhance therapeutic effect of glucosamine hydrochloride on rat arthritis through mechanism of antiinflammation.
3. D-glucosamine hydrochloride has antimicrobial effect on the common 21 strains of food spoilage microorganisms, it could as preservative agent was used to preserve nature eleo juice.
4. D-Glucosamine Hydrochloride has antitumor effects.
5. D-glucosamine hydrochloride induces cell apoptosis by blocking of cell-cycle.
1. 5-Hydroxy-4-methoxycanthin-6-one exhibits significant cytotoxic activity against CNE2 cell line.
2. 4-Methoxy-5- hydroxycanthin-6-one has anti-inflammatory effect, it can significantly inhibit the production of NO and the release of TNF-α induced by LPS in macrophage RAW 264.7.
3. After oral administration, 4-methoxy-5- hydroxycanthin-6-one (3, 9, and 27 mg/kg) can reduce the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats.
4. 4-Methoxy-5-hydroxycanthin-6-one has protective effect on dextran sulfate sodium -induced rat colitis.
1. Piperine inhibits drug-metabolizing enzymes in rodents and increases plasma concentrations of several drugs, including P-glycoprotein substrates (phenytoin and rifampin) in humans, it is an inhibitor of human P-glycoprotein and/or CYP3A4.
2. Piperine has immunomodulatory and antitumor activity.
3. Piperine has antidepressant like effects in chronic mild stress treated mice, up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity might be mechanisms involved in the antidepressant-like effect of piperine.
4. Administration of piperine appears to reverse preexisting high-fat diet (HFD)-induced hepatic steatosis and insulin resistance, probably by activation of adiponectin-AMPK signalling in mice.
5. Piperine has anti-inflammatory, antinociceptive, and antiarthritic effectsin human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models, thus, piperine should be further studied with regard to use either as a pharmaceutical or as a dietary supplement for the treatment of arthritis.
6. Piperine shows a lower hepatoprotective potency than silymarin(a known hepatoprotective drug).
7. Piperine displays the anti-oxidative, anti-apoptotic and chemo-protective properties in the DLM.
8. Piperine may be useful in the management of T lymphocyte-mediated autoimmune and chronic inflammatory disorders,may be as a drug to prevent or reduce the colonic inflammation by inducing PXR and CYP3A4 gene expression at the mRNA and protein levels.