1. Fisetin is an anti-inflammatory flavonoid, it has beneficial effect on periodontal disease, may via inhibiting MAPK activation and COX-2 expression without affecting cell viability.
2. Fisetin can ameliorate photodamage by suppressing the mitogen-activated protein Kinase/Matrix metalloproteinase pathway and nuclear factor-κB pathways.
3. Fisetin suppresses the accumulation of intracellular lipids by inhibiting GLUT4-mediated glucose uptake through inhibition of the mTOR-C/EBPα signaling in 3T3-L1 cells.
4. Fisetin has antimetastatic effects on prostate, breast and lung cancers.
5. Fisetin functions as a dual inhibitor of mTORC1/2 signaling leading to inhibition of prostate cancer (CaP)-dependent translation and induction of autophagic cell death in PC3 cells.
6. Fisetin has direct antioxidant activity, it can also increase the intracellular levels of glutathione (GSH), the major endogenous antioxidant, and fisetin has both neurotrophic and anti-inflammatory activity.
7. Fisetin shows in vitro antifungal activity( MIC<128 ug/mL) and low toxicity( (IC50=158 ug/mL) on animal cells.
1. Rhamnocitrin and kaempferol can augment cellular antioxidant defense capacity, at least in part, through regulation of HO-1 expression and MAPK signal transduction.
2. Rhamnocitrin and kaempferol not only protect low-density lipoprotein from oxidation but also prevent atherogenesis through suppressing macrophage uptake of oxidized low-density lipoprotein.
3. Rhamnocitrin can enhance the immune function, improve the formation of spleen cells of mice serum hemolysin of chicken red blood cell immune.
4. Rhamnocitrin shows a significant protection against cloudiness in lenses induced by hydrogen peroxide and hydrocortisone in a dose dependent manner, suggests that rhamnocitrin possesses significant anticataract activity and acts most likely due to its antioxidant property.
1. Lanosterol induces mild depolarization of mitochondria and promotes autophagy.
2. Lanosterol is indicative of altered Lanosterol metabolism during PD pathogenesis.
3. 10 μM Lanosterol during IVM in medium without serum and bases on recombinant human chorionic gonadotrophin has a positive effect on maturation of prepubertal ewe oocytes.