1. Rotundine combined with methadone treatment may be a better therapeutic method in treatment of heroin dependence.
2. Rotundine injection can ameliorate the damages by modulating the activities of different types of NOS, and the various types of NOS play different roles in the lung damages after brain I/R injury at different stages in rats; rotundine provides remarkable protection against cerebral ischemia reperfusion damage, its mechanisms may be through its influence on NO、ET 1 and energy metabolism.
1. Ibogaine has the propensity to prolong the QT interval of the electrocardiogram in humans, may generate life-threatening cardiac arrhythmias .
2. Ibogaine has promising anti-addictive property in animals.