1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects.
2. Mulberroside A elicits neuroprotective effects comparable to nimodipine, it exhibits anti-inflammatory and antiapoptotic effects, suggests that mulberroside A is a candidate for the treatment of ischemic stroke, which would act as a multifactorial neuroprotectant.
3. Mulberroside A exhibits uricosuric and nephroprotective effects mediated in part by cooperative attenuation of the expression alterations of renal organic ion transporters in hyperuricemic mice, suggests that it may be a new drug candidate for the treatment of hyperuricemia with renal dysfunction.
4. Mulberroside A can reduce the pigmentation in guinea pig skin, has anti-melanogenesis effects, thus, it may be suitable cosmetic agents for skin whitening.
5. cis-Mulberroside A shows high analgesic and anti-inflammatory activities.
6. cis-Mulberroside A can protect mice against ethanol-induced hepatic damage.
1. Nuciferine is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn that possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities.
2. Nuciferine is an important drug candidate for the treatment of obesity-related diseases, through ameliorating HFD-induced dyslipidemia as well as liver steatosis and injury.
3. Nuciferine may be potential for the prevention and treatment of hyperuricemia with kidney inflammation.
4. Nuciferine has a vasorelaxant effect via both endothelium-dependent and -independent mechanisms, suggests that nuciferine may have a therapeutic effect on vascular diseases associated with aberrant vasoconstriction.
5. Nuciferine, extracted from Nelumbo nucifera, can stimulate both phases of insulin secretion in isolated islets by closing potassium-adenosine triphosphate channels, explaining anti-diabetic effects of Nelumbo nucifera.
6. Nuciferine inhibits tumor-promoting effect of nicotine involving Wnt/β-catenin signaling in non-small cell lung cancer, it presents a potential novel alternative to NSCLC prevention and therapy.