1.(-)-Licarin B has anti-mycobacterial activity.
1. Ginsenoside Re is an effective antidiabetic agent via significant antioxidant efficacy, particularly in the prevention of diabetic microvasculopathy.
2. Ginsenoside Re is a protective agent for the heart against ischemia, by enhancing the slowly activating component of the delayed rectifier K+ current (IKs) and suppresses the L-type Ca2+ current (ICa,L) to shorten action potential duration(APD).
1. Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
2. Norathyriol can improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK.
3. Norathyriol exerts a potent chemopreventive activity by inhibiting Akt activation in neoplastic cell transformation.
4. Norathyriol as a safe new chemopreventive agent that is highly effective against development of UV-induced skin cancer.
1. Corosolic acid (CRA), a constituent of banaba leaves, has been reported to have anti-inflammatory and hypoglycemic activities, it can ameliorate hypertension, abnormal lipid metabolism, and oxidative stress as well as the inflammatory state in SHR-cp rats, suggests CRA can be beneficial for preventing atherosclerosis-related diseases.
2. Corosolic acid significantly inhibits cell viability in both a dose- and a time-dependent manner, induces apoptosis is associated with the activation of caspases via a mitochondrial pathway, suggests it could have strong potentials for clinical application in treating human cervix adenocarcinoma and improving cancer chemotherapy.
3. Corosolic acid can suppress the M2 polarization of macrophages and tumor cell proliferation by inhibiting both STAT3 and NF-κB activation, thus, it might be a potential new tool for tumor prevention and therapy.
4. Corosolic acid has antidiabetic effects(especially type 2 diabetes), can improve glucose metabolism by reducing insulin resistance, it inhibits the enzymatic activities of several diabetes-related non-receptor protein tyrosine phosphatases (PTPs) in vitro, such as PTP1B, T-cell-PTP, src homology phosphatase-1 and src homology phosphatase-2.
5. Corosolic acid has antitumor effects in murine sarcoma model through significantly impairing subcutaneous tumor development and lung metastasis and targeting the immunosuppressive activity of myeloid-derived suppressor cells (MDSC), and can enhance the antitumor effects of adriamycin and cisplatin in in vitro.