1. Picroside I possesses the properties of antioxidants,through the activity of superoxide dismutase, metal ion chelators and xanthine oxidase inhibitors.
1. Magnolin has anti-inflammatory and antioxidative effects.
2. Magnolin can ameliorate the renal tubular necrosis, apoptosis, and the deterioration of renal function.
3. Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.
4. Magnolin might be a naturally occurring chemoprevention and therapeutic agent capable of inhibiting cell proliferation and transformation by targeting ERK1 and ERK2.
|CFN90161||Ginkgolic acid C15:1
1. Ginkgolic acid C15:1 represses curli genes and prophage genes in EHEC.
1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner.
2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2.
3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.
|CFN90574||Lucidenic acid A
1. Lucidenic acid-A and -F are modulators of JNK and p38, respectively, they enhance LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK MAPKs activation.
2. Lucidenic acids A, B, C, and N (50 microM) in the presence of 200 nM phorbol 12-myristate 13-acetate (PMA) after 24 h of incubation all resulted in significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells.
3. Lucidenic acid A shows significant cytotoxic activity against Hep G2, Hep G2,2,15, and P-388 tumor cells.