1. Caryophyllene oxide shows significant central as well as peripheral analgesic, along with anti-inflammatory, activity at the doses of 12.5 and 25mg/kg body wt.
2. Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation.
3. Caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis.
4. Artemisia campestris ssp. campestris essential oils with dominant caryophyllene oxide are notably toxic.
5. Caryophyllene Oxide and lupenone have synergistic effect against Trypanosoma cruzi.
6. β-Caryophyllene oxide has acaricidal activities against house dust mites,it and structural analogues have potential for development as preventive agents for control of house dust mites.
1. Camaric acid possesses nematicidal activity.
1. Lupenone effectively inhibited adipocyte differentiation through downregulation of related transcription factor, particularly the PPARγ gene.
2. The in vitro trypanocidal activity of a 1 : 4 mixture of Lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4 μ g/mL, FIC = 0.46).
1. Horminone may inhibit the initial steps of protein synthesis.
2. After administration of plant extracts containing Horminone has possibility of toxic effect.
1. Conocarpan exhibits antifungal activity.
2. Conocarpan exhibits insecticidal, and antitrypanosomal activities.