1. Caryophyllene oxide has analgesic activity.
2. Caryophyllene oxide has anti-inflammatory activity.
3. Caryophyllene oxide inhibits the mitochondrial electron transport chain.
1. Lupenone effectively inhibited adipocyte differentiation through downregulation of related transcription factor, particularly the PPARγ gene.
2. The in vitro trypanocidal activity of a 1 : 4 mixture of Lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4 μ g/mL, FIC = 0.46).
1. Miltirone has anticancer activity.
2. Miltirone has antibacterial activity.
3. Miltirone has antioxidant and anti-inflammatory activities.
4. Miltirone is the likely active constituent of S. miltiorrhiza, can reduce effect of its extracts on alcohol intake in excessive alcohol consumption.
5. Miltirone may ameliorate the symptoms associated with discontinuation of long-term administration of ethanol or of other positive modulators of the GABA(A) receptor.
6. Miltirone is a CYPs inhibitor, is weaker than dihydrotanshinone, but stronger than cryptotanshinone, tanshinone I and tanshinone IIA.
1. N-p-coumaroyltyramine, an α-glucosidase inhibitor, isolated from methanol extracts of Welsh onion (Allium fistulosum), the inhibitory activity of it against a yeast enzyme is as high as Ki 8.4×10-7 M.
2.N-p-coumaroyl tyramine is an inhibitor on acetylcholinesterase (AChE), it inhibits AChE activity in a dose-dependent manner with IC50 value of 34.5 microg/mL (122 microM).
3. N-trans-p-coumaroyltyramine exhibits potent inhibition of cell proliferation, platelet aggregation, and shows antioxidant activity.
4. N-trans-p-coumaroyltyramine and N-trans-pcoumaroyloctopamine exhibit a strong suppressive effect on phagocytosis response upon activation with serum opsonized zymosan in the range of IC50 = 0.5-7.2 uM, they display weak cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3, with IC50 values ranging from 69.8 to 99.0 uM.
5. N-trans-p-coumaroyltyramine, N-trans-caffeoyltyramine, and N-trans-feruloyltyramine as the main active constituents of a methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) show activity against Trypanosoma brucei rhodesiense (IC50s ranging from 2.2 to 13.3 microM).
1. Pseudolycorine exhibits cytotoxic effect.