Glucosylvitexin can inhibit thyroid peroxidase (TPO) activity, thus it can produce goitrogenic and antithyroid effects similar to those of certain other antithyroid agents and small doses of methimazole (MMI).
Periplogenin plays protective roles against thyrotoxicosis and associated cardiovascular problems, are mediated through its direct antithyroidal and/or LPO inhibiting properties. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models.
1. Goitrin is a potent antithyroid compound found naturally in crucifers.
2. Goitrin is responsible for the induction of glutathione S-transferases.
3. Goitrin is a moderate inhibitor of purified bovine adrenal dopamine beta-hydroxylase, leads to a depression of brain norepinephrine and to an elevation of heart and adrenal dopamine.