1. Astragaloside II is a potent multidrug resistance (MDR) reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy.
2. Astragaloside II induces osteogenic activities of osteoblasts through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways, it may become a novel candidate that is beneficial for stimulating the osteoblastic activity resulting in bone formation.
3. Astragaloside II has immunomodulating activity, can trigger T cell activation through regulation of CD45 protein tyrosine phosphatase activity.
4. Astragaloside II can be served as autophagy inhibitor which restores chemosensitivity of anticancer agent cisplatin and enhances tumor cell death.
1. Liensinine and neferine can antagonize the ventricular arrhythmias, have inhibition of human ether-a-go-go-related gene (hERG).
2. Liensinine inhibits late-stage autophagy/mitophagy through blocking autophagosome- lysosome fusion, it could potentially be further developed as a novel autophagy/mitophagy inhibitor, and a combination of liensinine with classical chemotherapeutic drugs could represent a novel therapeutic strategy for treatment of breast cancer.
3. Liensinine exerts remarkable effect against thrombosis and possesses strong effect against platelet aggregation and coagulation.
1. Matrine possesses anti-inflammation, anti-fibrotic and anticancer, it could inhibit cell proliferation and induce apoptosis of SGC-7901 cells in vitro by up-regulating Fas/FasL expression and activating caspase-3 enzyme.
2. Matrine may be a potential alternative against invasive glioma cells via the p38 MAPK and AKT signaling‑dependent inhibition of EMT.
3. Matrine can be a potential candidate to fight against Candida-related infections by regulating yeast-to-hypha transition.
4. Matrine has anticancer property, which include the inhibition of human osteosarcoma cells invasion and proliferation , NPC cell migration and invasion , cisplatin resistance in NSCLC.
5. Matrine suppresses PMA-induced MMP-1 expression through inhibition of the AP-1 signaling pathway and also may be beneficial for treatment of some inflammatory skin disorders.
6. Matrine seems to be a novel autophagy inhibitor that can modulate the maturation process of lysosomal proteases.
7. Matrine has a protective effect on immunosuppression, a strong non-specific anti-inflammatory effect, and an effect of reducing the incidence of sodium and water retention.