Fructose is a simple ketonic monosaccharide found in many plants. Dietary fructose can specifically increase hepatic de novo lipogenesis (DNL), promote dyslipidemia, decreases insulin sensitivity, and increase visceral adiposity in overweight/obese adults; it also can reduce circulating insulin and leptin, attenuate postprandial suppression of ghrelin, and increase triglycerides in women.
1. Streptozotocin, which produces diabetes mellitus in experimental animals, has been reported to reduce the level of NAD in pancreatic isletsand to inhibit islet synthesis of proinsulin.
2. Streptozotocin can induce pancreatic insulitis, which is a new model of diabetes mellitus.