1. Caffeic acid has anticarcinogenic effects, it can suppress ultraviolet B(UVB)-induced COX-2 expression by blocking Fyn kinase activity, suggests that this compound could act as a potent chemopreventive agent against skin cancer.
2. Caffeic acid inhibits HBV-DNA replication as well as HBsAg production, also reduces serum DHBV level in DHBV-infected duckling model.
3. Caffeic acid is a potent antioxidant which presents important anti-inflammatory actions, being its actions mediated, at least in part by the scavenging of NO and its ability to modulate iNOS expression and probably that of other inflammatory mediators.
4. Caffeic acid exhibits a significant potential as an antidiabetic agent by suppressing a progression of type 2 diabetic states that is suggested by an attenuation of hepatic glucose output and enhancement of adipocyte glucose uptake, insulin secretion, and antioxidant capacity.
5. Inhibitory activity of Caffeic acid against α-synuclein fibrillation may guide us in designing novel therapeutic drugs for Parkinson's disease.
1. Alpha-lipoic acid has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food, it is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age.
2. Alpha-lipoic acid can enhance glucose transport and utilization in different experimental and animal models, it can improve insulin sensitivity in patients with type-2 diabetes.
3. Lipoic acid is a novel treatment for Alzheimer's disease and related dementias.
4. Alpha-lipoic acid has therapeutic effects on joint inflammation and erosion in an animal model via NF-kappa B down regulation, it inhibits TNF-alpha induced NF-kappa B activation through blocking of MEKK1-MKK4-IKK signaling cascades.
1. Conophylline plays a key role in the regulation of cell mass proliferation, maintenance of the undifferentiated state of iPMSCs and also promotes iPMSCs differentiated into insulin-producing cells.
2. Conophylline down-regulates the expression of the TNF-α receptors on the cell surface.
3. Conophylline is a novel differentiation inducer for pancreatic β cells, can increase the numbers of ductal cells positive for pancreatic-duodenal-homeobox protein-1 and islet-like cell clusters.
4. Conophylline has been shown to induce differentiation of pancreatic AR42J cells and increases the formation of beta-cells.
5. Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats.
6. Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mTOR-independent autophagy.
7. Conophylline suppresses hepatic stellate cells and attenuates thioacetamide-induced liver fibrosis in rats.
1. Betaine is an important nutrient for the prevention of chronic disease.
2. Betaine is an osmolyte to protect cells, proteins, and enzymes from environmental stress (eg, low water, high salinity, or extreme temperature).
3. Betaine is a methyl donor to participate in the methionine cycle—primarily in the human liver and kidneys.
4. Betaine can protect internal organs, improve vascular risk factors, and enhance performance.
1. Stevioside is a safe natural sweetener, has no allergic reactions, suited for both diabetics, and PKU patients, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet.
2. Stevioside exerts anti-inflammatory and anti-apoptotic properties by inhibiting the release of cytokines and the activation of TLR2 and proteins of the NF-κB and MAPK signaling pathways, as well as caspase-3 and Bax.
3. Stevioside and steviol attenuate LPS-induced pro-inflammatory cytokine productions by affecting cytokine gene expression via IκBα/NF-κB signalling pathway.